Tumor necrosis factor receptor superfamily member 19L

UniProt data

UniProt name: TR19L_HUMAN (Q969Z4)

Gene name: RELT; Synonyms=TNFRSF19L

Organism: Homo sapiens (Human).

Function: Mediates activation of NF-kappa-B. May play a role in T- cell activation.

Subcellular location: Cell membrane {ECO:0000269|PubMed:16389068}; Single-pass type I membrane protein {ECO:0000269|PubMed:16389068}. Cytoplasm {ECO:0000269|PubMed:16389068}.

Transmembrane domains:

  1. 163-183, 21 AA, Helical. {ECO:0000255}.

Sequence: 430 AA

10 20 30 40 50 60 MKPSLLCRPL SCFLMLLPWP LATLTSTTLW QCPPGEEPDL DPGQGTLCRP CPPGTFSAAW 70 80 90 100 110 120 GSSPCQPHAR CSLWRRLEAQ VGMATRDTLC GDCWPGWFGP WGVPRVPCQP CSWAPLGTHG 130 140 150 160 170 180 CDEWGRRARR GVEVAAGASS GGETRQPGNG TRAGGPEETA AQYAVIAIVP VFCLMGLLGI 190 200 210 220 230 240 LVCNLLKRKG YHCTAHKEVG PGPGGGGSGI NPAYRTEDAN EDTIGVLVRL ITEKKENAAA 250 260 270 280 290 300 LEELLKEYHS KQLVQTSHRP VSKLPPAPPN VPHICPHRHH LHTVQGLASL SGPCCSRCSQ 310 320 330 340 350 360 KKWPEVLLSP EAVAATTPVP SLLPNPTRVP KAGAKAGRQG EITILSVGRF RVARIPEQRT 370 380 390 400 410 420 SSMVSEVKTI TEAGPSWGDL PDSPQPGLPP EQQALLGSGG SRTKWLKPPA ENKAEENRYV VRLSESNLVI

CATM prediction

The sequence of TR19L_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  160       170       180    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 AAQYAVIAIVAVFCLMGLLGILVCNLL 7.0 -47.3° 2.2 45.1 -39.6
Prolines* AAQYAVIAIVPVFCLMGLLGILVCNLL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 176, GLY, HA2 A, 175, MET, O 3.15Å
B, 179, GLY, HA1 A, 176, GLY, O 2.95Å
B, 180, ILE, HA A, 179, GLY, O 3.43Å
A, 176, GLY, HA2 B, 175, MET, O 3.15Å
A, 179, GLY, HA1 B, 176, GLY, O 2.95Å
A, 180, ILE, HA B, 179, GLY, O 3.43Å