Nicalin

UniProt data

UniProt name: NCLN_HUMAN (Q969V3)

Gene name: NCLN

Organism: Homo sapiens (Human).

Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. {ECO:0000250}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}; Single-pass membrane protein {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}.

Transmembrane domains:

  1. 523-543, 21 AA, Helical. {ECO:0000255}.

Sequence: 563 AA

10 20 30 40 50 60 MLEEAGEVLE NMLKASCLPL GFIVFLPAVL LLVAPPLPAA DAAHEFTVYR MQQYDLQGQP 70 80 90 100 110 120 YGTRNAVLNT EARTMAAEVL SRRCVLMRLL DFSYEQYQKA LRQSAGAVVI ILPRAMAAVP 130 140 150 160 170 180 QDVVRQFMEI EPEMLAMETA VPVYFAVEDE ALLSIYKQTQ AASASQGSAS AAEVLLRTAT 190 200 210 220 230 240 ANGFQMVTSG VQSKAVSDWL IASVEGRLTG LGGEDLPTIV IVAHYDAFGV APWLSLGADS 250 260 270 280 290 300 NGSGVSVLLE LARLFSRLYT YKRTHAAYNL LFFASGGGKF NYQGTKRWLE DNLDHTDSSL 310 320 330 340 350 360 LQDNVAFVLC LDTVGRGSSL HLHVSKPPRE GTLQHAFLRE LETVAAHQFP EVRFSMVHKR 370 380 390 400 410 420 INLAEDVLAW EHERFAIRRL PAFTLSHLES HRDGQRSSIM DVRSRVDSKT LTRNTRIIAE 430 440 450 460 470 480 ALTRVIYNLT EKGTPPDMPV FTEQMQIQQE QLDSVMDWLT NQPRAAQLVD KDSTFLSTLE 490 500 510 520 530 540 HHLSRYLKDV KQHHVKADKR DPEFVFYDQL KQVMNAYRVK PAVFDLLLAV GIAAYLGMAY 550 560 VAVQHFSLLY KTVQRLLVKA KTQ

CATM prediction

The sequence of NCLN_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  520       530       540    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 KAAVFDLLLAVGIAAYLGMAYVAVQHF 7.0 -51.9° 5.3 39.4 -9.0
Prolines* KPAVFDLLLAVGIAAYLGMAYVAVQHF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 534, ALA, HA A, 533, ALA, O 3.11Å
B, 537, GLY, HA1 A, 534, ALA, O 3.48Å
A, 534, ALA, HA B, 533, ALA, O 3.11Å
A, 537, GLY, HA1 B, 534, ALA, O 3.48Å