Immunoglobulin superfamily member 8

UniProt data

UniProt name: IGSF8_HUMAN (Q969P0)

Gene name: IGSF8; Synonyms=CD81P3, EWI2, KCT4

Organism: Homo sapiens (Human).

Function: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. {ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:12750295, ECO:0000269|PubMed:12752121, ECO:0000269|PubMed:14662754, ECO:0000269|PubMed:15070678}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein.

Transmembrane domains:

  1. 580-600, 21 AA, Helical. {ECO:0000255}.

Sequence: 613 AA

10 20 30 40 50 60 MGALRPTLLP PSLPLLLLLM LGMGCWAREV LVPEGPLYRV AGTAVSISCN VTGYEGPAQQ 70 80 90 100 110 120 NFEWFLYRPE APDTALGIVS TKDTQFSYAV FKSRVVAGEV QVQRLQGDAV VLKIARLQAQ 130 140 150 160 170 180 DAGIYECHTP STDTRYLGSY SGKVELRVLP DVLQVSAAPP GPRGRQAPTS PPRMTVHEGQ 190 200 210 220 230 240 ELALGCLART STQKHTHLAV SFGRSVPEAP VGRSTLQEVV GIRSDLAVEA GAPYAERLAA 250 260 270 280 290 300 GELRLGKEGT DRYRMVVGGA QAGDAGTYHC TAAEWIQDPD GSWAQIAEKR AVLAHVDVQT 310 320 330 340 350 360 LSSQLAVTVG PGERRIGPGE PLELLCNVSG ALPPAGRHAA YSVGWEMAPA GAPGPGRLVA 370 380 390 400 410 420 QLDTEGVGSL GPGYEGRHIA MEKVASRTYR LRLEAARPGD AGTYRCLAKA YVRGSGTRLR 430 440 450 460 470 480 EAASARSRPL PVHVREEGVV LEAVAWLAGG TVYRGETASL LCNISVRGGP PGLRLAASWW 490 500 510 520 530 540 VERPEDGELS SVPAQLVGGV GQDGVAELGV RPGGGPVSVE LVGPRSHRLR LHSLGPEDEG 550 560 570 580 590 600 VYHCAPSAWV QHADYSWYQA GSARSGPVTV YPYMHALDTL FVPLLVGTGV ALVTGATVLG 610 TITCCFMKRL RKR

CATM prediction

The sequence of IGSF8_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     580       590       600 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 LDTLFVALLVGTGVALVTGATVLGTIT 7.0 -43.3° 2.4 44.0 -21.9
Prolines* LDTLFVPLLVGTGVALVTGATVLGTIT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 584, LEU, HA A, 583, ALA, O 3.07Å
B, 587, GLY, HA1 A, 584, LEU, O 2.97Å
B, 588, THR, HA A, 587, GLY, O 3.39Å
A, 584, LEU, HA B, 583, ALA, O 3.07Å
A, 587, GLY, HA1 B, 584, LEU, O 2.97Å
A, 588, THR, HA B, 587, GLY, O 3.39Å