Tumor necrosis factor receptor superfamily member 25

UniProt data

UniProt name: TNR25_HUMAN (Q93038)

Gene name: TNFRSF25; Synonyms=APO3, DDR3, DR3, TNFRSF12, WSL, WSL1

Organism: Homo sapiens (Human).

Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Subcellular location: Isoform 12: Secreted.

Transmembrane domains:

  1. 200-220, 21 AA, Helical. {ECO:0000255}.

Sequence: 417 AA

10 20 30 40 50 60 MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 70 80 90 100 110 120 CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 130 140 150 160 170 180 WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 190 200 210 220 230 240 TSTLGSCPER CAAVCGWRQM FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTADEAG 250 260 270 280 290 300 MEALTPPPAT HLSPLDSAHT LLAPPDSSEK ICTVQLVGNS WTPGYPETQE ALCPQVTWSW 310 320 330 340 350 360 DQLPSRALGP AAAPTLSPES PAGSPAMMLQ PGPQLYDVMD AVPARRWKEF VRTLGLREAE 370 380 390 400 410 IEAVEVEIGR FRDQQYEMLK RWRQQQPAGL GAVYAALERM GLDGCVEDLR SRLQRGP

CATM prediction

The sequence of TNR25_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     200       210       220 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 WRQMFWVQVLLAGLVVALLLGATLTYT 7.3 -43.9° 1.8 45.1 -33.5
Model 2 WRQMFWVQVLLAGLVVALLLGATLTYT 7.2 -41.1° 3.4 38.4 -28.1
Prolines* WRQMFWVQVLLAGLVVPLLLGATLTYT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 206, LEU, HA A, 205, VAL, O 3.49Å
B, 209, GLY, HA1 A, 206, LEU, O 3.28Å
A, 206, LEU, HA B, 205, VAL, O 3.49Å
A, 209, GLY, HA1 B, 206, LEU, O 3.28Å