Tumor necrosis factor receptor superfamily member 14

UniProt data

UniProt name: TNR14_HUMAN (Q92956)

Gene name: TNFRSF14; Synonyms=HVEA, HVEM; ORFNames=UNQ329/PRO509

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 203-223, 21 AA, Helical. {ECO:0000255}.

Sequence: 283 AA

10 20 30 40 50 60 MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG SECCPKCSPG 70 80 90 100 110 120 YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD PAMGLRASRN CSRTENAVCG 130 140 150 160 170 180 CSPGHFCIVQ DGDHCAACRA YATSSPGQRV QKGGTESQDT LCQNCPPGTF SPNGTLEECQ 190 200 210 220 230 240 HQTKCSWLVT KAGAGTSSSH WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS 250 260 270 280 VQRKRQEAEG EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH

CATM prediction

The sequence of TNR14_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  200       210       220    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 HWVWWFLSGSLVIVIVCSTVGLIICVK 6.9 -52.0° 1.3 57.3 -6.9
Model 2 HWVWWFLSGSLVIVIVCSTVGLIICVK 7.4 -50.9° 3.3 48.1 -2.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 217, SER, HA A, 216, CYS, O 3.11Å
B, 220, GLY, HA1 A, 217, SER, O 2.76Å
B, 221, LEU, HA A, 220, GLY, O 3.27Å
A, 217, SER, HA B, 216, CYS, O 3.11Å
A, 220, GLY, HA1 B, 217, SER, O 2.76Å
A, 221, LEU, HA B, 220, GLY, O 3.27Å