Neuronal cell adhesion molecule

UniProt data

UniProt name: NRCAM_HUMAN (Q92823)

Gene name: NRCAM; Synonyms=KIAA0343

Organism: Homo sapiens (Human).

Function: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q810U4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q810U4}. Cell projection, axon {ECO:0000250|UniProtKB:Q810U4}. Secreted {ECO:0000250|UniProtKB:Q810U4}. Note=Detected at nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.

Transmembrane domains:

  1. 1168-1190, 23 AA, Helical. {ECO:0000255}.

Sequence: 1304 AA

10 20 30 40 50 60 MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP 70 80 90 100 110 120 RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV 130 140 150 160 170 180 YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW 190 200 210 220 230 240 MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS 250 260 270 280 290 300 VDELNDTIAA NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP 310 320 330 340 350 360 IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH HTISVRVKAA 370 380 390 400 410 420 PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP IEIAPDDPSR KIDGDTIIFS 430 440 450 460 470 480 NVQERSSAVY QCNASNEYGY LLANAFVNVL AEPPRILTPA NTLYQVIANR PALLDCAFFG 490 500 510 520 530 540 SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL 550 560 570 580 590 600 EIKDPTWIVK QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH 610 620 630 640 650 660 LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP FDLELTDQLD 670 680 690 700 710 720 KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV SGTQTTAQLK LSPYVNYSFR 730 740 750 760 770 780 VMAVNSIGKS LPSEASEQYL TKASEPDKNP TAVEGLGSEP DNLVITWKPL NGFESNGPGL 790 800 810 820 830 840 QYKVSWRQKD GDDEWTSVVV ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS 850 860 870 880 890 900 GEDLPMVAPG NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE 910 920 930 940 950 960 KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG VPSAPSSLKI 970 980 990 1000 1010 1020 VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP LVDLKIPANK TRWTLKNLNF 1030 1040 1050 1060 1070 1080 STRYKFYFYA QTSAGSGSQI TEEAVTTVDE AGILPPDVGA GKVQAVNPRI SNLTAAAAET 1090 1100 1110 1120 1130 1140 YANISWEYEG PEHVNFYVEY GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG 1150 1160 1170 1180 1190 1200 DSGFVSSEDV FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV 1210 1220 1230 1240 1250 1260 KEKEDAHADP EIQPMKEDDG TFGEYSDAED HKPLKKGSRT PSDRTVKKED SDDSLVDYGE 1270 1280 1290 1300 GVNGQFNEDG SFIGQYSGKK EKEPAEGNES SEAPSPVNAM NSFV

CATM prediction

The sequence of NRCAM_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       1170      1180      1190
+    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 ATQGWFIGLMCAVALLILILLIVCFIRRN 7.0 -43.0° 3.5 50.0 -22.5
Model 2 ATQGWFIGLMCAVALLILILLIVCFIRRN 7.3 -27.0° 6.0 58.0 -13.6
Model 3 ATQGWFIGLMCAVALLILILLIVCFIRRN 6.7 -53.4° 5.2 58.0 -5.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1169, TRP, HA A, 1168, GLY, O 2.88Å
B, 1172, GLY, HA1 A, 1169, TRP, O 3.11Å
A, 1169, TRP, HA B, 1168, GLY, O 2.88Å
A, 1172, GLY, HA1 B, 1169, TRP, O 3.11Å