Receptor-type tyrosine-protein phosphatase U

UniProt data

UniProt name: PTPRU_HUMAN (Q92729)

Gene name: PTPRU; Synonyms=FMI, PCP2, PTPRO

Organism: Homo sapiens (Human).

Function: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}.

Subcellular location: Cell junction {ECO:0000269|PubMed:8700514}. Cell membrane {ECO:0000269|PubMed:8700514}; Single-pass type I membrane protein {ECO:0000269|PubMed:8700514}.

Transmembrane domains:

  1. 750-770, 21 AA, Helical. {ECO:0000255}.

Sequence: 1446 AA

10 20 30 40 50 60 MARAQALVLA LTFQLCAPET ETPAAGCTFE EASDPAVPCE YSQAQYDDFQ WEQVRIHPGT 70 80 90 100 110 120 RAPADLPHGS YLMVNTSQHA PGQRAHVIFQ SLSENDTHCV QFSYFLYSRD GHSPGTLGVY 130 140 150 160 170 180 VRVNGGPLGS AVWNMTGSHG RQWHQAELAV STFWPNEYQV LFEALISPDR RGYMGLDDIL 190 200 210 220 230 240 LLSYPCAKAP HFSRLGDVEV NAGQNASFQC MAAGRAAEAE RFLLQRQSGA LVPAAGVRHI 250 260 270 280 290 300 SHRRFLATFP LAAVSRAEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT 310 320 330 340 350 360 YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVSLQ TYKLWHLDPD TEYEISVLLT 370 380 390 400 410 420 RPGDGGTGRP GPPLISRTKC AEPMRAPKGL AFAEIQARQL TLQWEPLGYN VTRCHTYTVS 430 440 450 460 470 480 LCYHYTLGSS HNQTIRECVK TEQGVSRYTI KNLLPYRNVH VRLVLTNPEG RKEGKEVTFQ 490 500 510 520 530 540 TDEDVPSGIA AESLTFTPLE DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR 550 560 570 580 590 600 RTISKLRNET YHVFSNLHPG TTYLFSVRAR TGKGFGQAAL TEITTNISAP SFDYADMPSP 610 620 630 640 650 660 LGESENTITV LLRPAQGRGA PISVYQVIVE EERARRLRRE PGGQDCFPVP LTFEAALARG 670 680 690 700 710 720 LVHYFGAELA ASSLPEAMPF TVGDNQTYRG FWNPPLEPRK AYLIYFQAAS HLKGETRLNC 730 740 750 760 770 780 IRIARKAACK ESKRPLEVSQ RSEEMGLILG ICAGGLAVLI LLLGAIIVII RKGRDHYAYS 790 800 810 820 830 840 YYPKPVNMTK ATVNYRQEKT HMMSAVDRSF TDQSTLQEDE RLGLSFMDTH GYSTRGDQRS 850 860 870 880 890 900 GGVTEASSLL GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES 910 920 930 940 950 960 FFEGWDATKK KDKVKGSRQE PMPAYDRHRV KLHPMLGDPN ADYINANYID GYHRSNHFIA 970 980 990 1000 1010 1020 TQGPKPEMVY DFWRMVWQEH CSSIVMITKL VEVGRVKCSR YWPEDSDTYG DIKIMLVKTE 1030 1040 1050 1060 1070 1080 TLAEYVVRTF ALERRGYSAR HEVRQFHFTA WPEHGVPYHA TGLLAFIRRV KASTPPDAGP 1090 1100 1110 1120 1130 1140 IVIHCSAGTG RTGCYIVLDV MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA 1150 1160 1170 1180 1190 1200 ILEACLCGET TIPVSEFKAT YKEMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL 1210 1220 1230 1240 1250 1260 PRNRDKNRSM DVLPPDRCLP FLISTDGDSN NYINAALTDS YTRSAAFIVT LHPLQSTTPD 1270 1280 1290 1300 1310 1320 FWRLVYDYGC TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY GLMEVEFMSG TADEDLVARV 1330 1340 1350 1360 1370 1380 FRVQNISRLQ EGHLLVRHFQ FLRWSAYRDT PDSKKAFLHL LAEVDKWQAE SGDGRTIVHC 1390 1400 1410 1420 1430 1440 LNGGGRSGTF CACATVLEMI RCHNLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL EGLESR

CATM prediction

The sequence of PTPRU_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     750       760       770 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 LILGICAGGLAVLILLLGAIIVIIRKG 7.2 -51.0° 2.4 45.3 -11.6
Model 2 LILGICAGGLAVLILLLGAIIVIIRKG 7.4 -50.2° 2.9 47.0 -2.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 751, ILE, HA A, 750, GLY, O 3.20Å
B, 754, GLY, HA1 A, 751, ILE, O 3.05Å
A, 751, ILE, HA B, 750, GLY, O 3.20Å
A, 754, GLY, HA1 B, 751, ILE, O 3.05Å