UniProt data
UniProt name: NECT2_HUMAN (Q92692)
Gene name: NECTIN2 {ECO:0000312|HGNC:HGNC:9707}; Synonyms=HVEB, PRR2, PVRL2
Organism: Homo sapiens (Human).
Function: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV- 2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 361-381, 21 AA, Helical. {ECO:0000255}.
Sequence: 538 AA
CATM prediction
The sequence of NECT2_HUMAN returned 6 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 360 370 380 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | TGGIIGGIIAAIIATAVAATGILICRQ | 6.8 | -46.1° | 2.7 | 47.0 | -29.4 |
| Model 2 | TGGIIGGIIAAIIATAVAATGILICRQ | 7.2 | -44.2° | 1.8 | 45.0 | -28.2 |
| Model 3 | TGGIIGGIIAAIIATAVAATGILICRQ | 7.2 | -37.0° | 2.2 | 36.1 | -17.7 |
| Model 4 | TGGIIGGIIAAIIATAVAATGILICRQ | 6.6 | -55.0° | 5.0 | 53.0 | -14.2 |
| Model 5 | TGGIIGGIIAAIIATAVAATGILICRQ | 7.1 | -43.0° | 0.0 | 34.0 | -14.0 |
| Model 6 | TGGIIGGIIAAIIATAVAATGILICRQ | 6.6 | -46.0° | 3.6 | 37.0 | -5.2 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 364, GLY, HA1 | A, 361, ILE, O | 2.78Å |
| B, 365, ILE, HA | A, 364, GLY, O | 3.38Å |
| A, 364, GLY, HA1 | B, 361, ILE, O | 2.78Å |
| A, 365, ILE, HA | B, 364, GLY, O | 3.38Å |
