Transmembrane O-methyltransferase {ECO:0000250|UniProtKB:A1Y9I9}

UniProt data

UniProt name: TOMT_HUMAN (Q8WZ04)

Gene name: LRTOMT; Synonyms=COMT2 {ECO:0000303|PubMed:18794526}, TOMT

Organism: Homo sapiens (Human).

Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. {ECO:0000250|UniProtKB:P21964, ECO:0000269|PubMed:18794526}.

Subcellular location: Isoform 2: Cytoplasm {ECO:0000250}.

Transmembrane domains:

  1. 31-51, 21 AA, Helical. {ECO:0000255}.

Sequence: 291 AA

10 20 30 40 50 60 MGTPWRKRKG IAGPGLPDLS CALVLQPRAQ VGTMSPAIAL AFLPLVVTLL VRYRHYFRLL 70 80 90 100 110 120 VRTVLLRSLR DCLSGLRIEE RAFSYVLTHA LPGDPGHILT TLDHWSSRCE YLSHMGPVKG 130 140 150 160 170 180 QILMRLVEEK APACVLELGT YCGYSTLLIA RALPPGGRLL TVERDPRTAA VAEKLIRLAG 190 200 210 220 230 240 FDEHMVELIV GSSEDVIPCL RTQYQLSRAD LVLLAHRPRC YLRDLQLLEA HALLPAGATV 250 260 270 280 290 LADHVLFPGA PRFLQYAKSC GRYRCRLHHT GLPDFPAIKD GIAQLTYAGP G

CATM prediction

The sequence of TOMT_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    30        40        50   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 RAQVGTMSAAIALAFLALVVTLLVRYR 7.0 -38.0° 5.7 34.0 -1.6
Prolines* RAQVGTMSPAIALAFLPLVVTLLVRYR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session