Contactin-associated protein-like 5

UniProt data

UniProt name: CNTP5_HUMAN (Q8WYK1)

Gene name: CNTNAP5; Synonyms=CASPR5

Organism: Homo sapiens (Human).

Function: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1238-1258, 21 AA, Helical. {ECO:0000255}.

Sequence: 1306 AA

10 20 30 40 50 60 MDSLPRLTSV LTLLFSGLWH LGLTATNYNC DDPLASLLSP MAFSSSSDLT GTHSPAQLNW 70 80 90 100 110 120 RVGTGGWSPA DSNAQQWLQM DLGNRVEITA VATQGRYGSS DWVTSYSLMF SDTGRNWKQY 130 140 150 160 170 180 KQEDSIWTFA GNMNADSVVH HKLLHSVRAR FVRFVPLEWN PSGKIGMRVE VYGCSYKSDV 190 200 210 220 230 240 ADFDGRSSLL YRFNQKLMST LKDVISLKFK SMQGDGVLFH GEGQRGDHIT LELQKGRLAL 250 260 270 280 290 300 HLNLGDSKAR LSSSLPSATL GSLLDDQHWH SVLIERVGKQ VNFTVDKHTQ HFRTKGETDA 310 320 330 340 350 360 LDIDYELSFG GIPVPGKPGT FLKKNFHGCI ENLYYNGVNI IDLAKRRKHQ IYTGNVTFSC 370 380 390 400 410 420 SEPQIVPITF VNSSGSYLLL PGTPQIDGLS VSFQFRTWNK DGLLLSTELS EGSGTLLLSL 430 440 450 460 470 480 EGGILRLVIQ KMTERVAEIL TGSNLNDGLW HSVSINARRN RITLTLDDEA APPAPDSTWV 490 500 510 520 530 540 QIYSGNSYYF GGCPDNLTDS QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGNFSDLH 550 560 570 580 590 600 IDLCSIKDRC LPNYCEHGGS CSQSWTTFYC NCSDTSYTGA TCHNSIYEQS CEVYRHQGNT 610 620 630 640 650 660 AGFFYIDSDG SGPLGPLQVY CNITEDKIWT SVQHNNTELT RVRGANPEKP YAMALDYGGS 670 680 690 700 710 720 MEQLEAVIDG SEHCEQEVAY HCRRSRLLNT PDGTPFTWWI GRSNERHPYW GGSPPGVQQC 730 740 750 760 770 780 ECGLDESCLD IQHFCNCDAD KDEWTNDTGF LSFKDHLPVT QIVITDTDRS NSEAAWRIGP 790 800 810 820 830 840 LRCYGDRRFW NAVSFYTEAS YLHFPTFHAE FSADISFFFK TTALSGVFLE NLGIKDFIRL 850 860 870 880 890 900 EISSPSEITF AIDVGNGPVE LVVQSPSLLN DNQWHYVRAE RNLKETSLQV DNLPRSTRET 910 920 930 940 950 960 SEEGHFRLQL NSQLFVGGTS SRQKGFLGCI RSLHLNGQKM DLEERAKVTS GVRPGCPGHC 970 980 990 1000 1010 1020 SSYGSICHNG GKCVEKHNGY LCDCTNSPYE GPFCKKEVSA VFEAGTSVTY MFQEPYPVTK 1030 1040 1050 1060 1070 1080 NISLSSSAIY TDSAPSKENI ALSFVTTQAP SLLLFINSSS QDFVVVLLCK NGSLQVRYHL 1090 1100 1110 1120 1130 1140 NKEETHVFTI DADNFANRRM HHLKINREGR ELTIQMDQQL RLSYNFSPEV EFRVIRSLTL 1150 1160 1170 1180 1190 1200 GKVTENLGLD SEVAKANAMG FAGCMSSVQY NHIAPLKAAL RHATVAPVTV HGTLTESSCG 1210 1220 1230 1240 1250 1260 FMVDSDVNAV TTVHSSSDPF GKTDEREPLT NAVRSDSAVI GGVIAVVIFI IFCIIGIMTR 1270 1280 1290 1300 FLYQHKQSHR TSQMKEKEYP ENLDSSFRNE IDLQNTVSEC KREYFI

CATM prediction

The sequence of CNTP5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       1240      1250      12
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 SDSAVIGGVIAVVIFIIFCIIGIMTRF 6.7 -40.0° 4.0 38.0 -23.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1241, GLY, HA1 A, 1238, ALA, O 2.83Å
B, 1242, GLY, HA2 A, 1241, GLY, O 3.48Å
A, 1241, GLY, HA1 B, 1238, ALA, O 2.83Å
A, 1242, GLY, HA2 B, 1241, GLY, O 3.48Å