T-complex protein 11 homolog

UniProt data

UniProt name: TCP11_HUMAN (Q8WWU5)

Gene name: TCP11

Organism: Homo sapiens (Human).

Function: May play an important role in sperm function and fertility. {ECO:0000269|PubMed:11756566}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 330-349, 20 AA, Helical. {ECO:0000255}.

Sequence: 503 AA

10 20 30 40 50 60 MPDVKESVPP KYPGDSEGRS CKPETSGPPQ EDKSGSEDPP PFLSVTGLTE TVNEVSKLSN 70 80 90 100 110 120 KIGMNCDYYM EEKVLPPSSL EGKVKETVHN AFWDHLKEQL SATPPDFSCA LELLKEIKEI 130 140 150 160 170 180 LLSLLLPRQN RLRIEIEEAL DMDLLKQEAE HGALKVLYLS KYVLNMMALL CAPVRDEAVQ 190 200 210 220 230 240 KLENITDPVW LLRGIFQVLG RMKMDMVNYT IQSLQPHLQE HSIQYERAKF QELLNKQPSL 250 260 270 280 290 300 LNHTTKWLTQ AAGDLTMSPP TCPDTSDSSS VAGPSPNEAA NNPEPLSPTM VLCQGFLNLL 310 320 330 340 350 360 LWDLENEEFP ETLLMDRTRL QELKSQLHQL TVMASVLLVA SSFSGSVLFG SPQFVDKLKR 370 380 390 400 410 420 ITKSLLEDFH SRPEEAILTV SEQVSQEIHQ SLKNMGLVAL SSDNTASLMG QLQNIAKKEN 430 440 450 460 470 480 CVCSVIDQRI HLFLKCCLVL GVQRSLLDLP GGLTLIEAEL AELGQKFVNL THHNQQVFGP 490 500 YYTEILKTLI SPAQALETKV ESV

CATM prediction

The sequence of TCP11_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     330       340       350
   |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LHQLTVMASVLLVASSFSGSVLFGSA 6.9 -47.5° 3.3 34.2 -16.0
Prolines* LHQLTVMASVLLVASSFSGSVLFGSP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 338, LEU, HA A, 341, SER, OG 3.30Å
B, 342, SER, HA A, 341, SER, O 3.08Å
B, 345, GLY, HA1 A, 342, SER, O 2.95Å
A, 338, LEU, HA B, 341, SER, OG 3.29Å
A, 342, SER, HA B, 341, SER, O 3.08Å
A, 345, GLY, HA1 B, 342, SER, O 2.95Å