Stabilin-2

UniProt data

UniProt name: STAB2_HUMAN (Q8WWQ8)

Gene name: STAB2 {ECO:0000312|EMBL:CAC82105.1}

Organism: Homo sapiens (Human).

Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:15208308, ECO:0000269|PubMed:15572036, ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18434317, ECO:0000269|PubMed:18573870, ECO:0000269|PubMed:19359419}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:17675564}; Single-pass type I membrane protein {ECO:0000269|PubMed:17675564}. Cytoplasm {ECO:0000269|PubMed:17145755}. Note=Only a small amount appears to be present at the cell surface (PubMed:17145755).

Transmembrane domains:

  1. 2459-2479, 21 AA, Helical. {ECO:0000255}.

Sequence: 2551 AA

10 20 30 40 50 60 MMLQHLVIFC LGLVVQNFCS PAETTGQARR CDRKSLLTIR TECRSCALNL GVKCPDGYTM 70 80 90 100 110 120 ITSGSVGVRD CRYTFEVRTY SLSLPGCRHI CRKDYLQPRC CPGRWGPDCI ECPGGAGSPC 130 140 150 160 170 180 NGRGSCAEGM EGNGTCSCQE GFGGTACETC ADDNLFGPSC SSVCNCVHGV CNSGLDGDGT 190 200 210 220 230 240 CECYSAYTGP KCDKPIPECA ALLCPENSRC SPSTEDENKL ECKCLPNYRG DGKYCDPINP 250 260 270 280 290 300 CLRKICHPHA HCTYLGPNRH SCTCQEGYRG DGQVCLPVDP CQINFGNCPT KSTVCKYDGP 310 320 330 340 350 360 GQSHCECKEH YQNFVPGVGC SMTDICKSDN PCHRNANCTT VAPGRTECIC QKGYVGDGLT 370 380 390 400 410 420 CYGNIMERLR ELNTEPRGKW QGRLTSFISL LDKAYAWPLS KLGPFTVLLP TDKGLKGFNV 430 440 450 460 470 480 NELLVDNKAA QYFVKLHIIA GQMNIEYMNN TDMFYTLTGK SGEIFNSDKD NQIKLKLHGG 490 500 510 520 530 540 KKKVKIIQGD IIASNGLLHI LDRAMDKLEP TFESNNEQTI MTMLQPRYSK FRSLLEETNL 550 560 570 580 590 600 GHALDEDGVG GPYTIFVPNN EALNNMKDGT LDYLLSPEGS RKLLELVRYH IVPFTQLEVA 610 620 630 640 650 660 TLISTPHIRS MANQLIQFNT TDNGQILAND VAMEEIEITA KNGRIYTLTG VLIPPSIVPI 670 680 690 700 710 720 LPHRCDETKR EMKLGTCVSC SLVYWSRCPA NSEPTALFTH RCVYSGRFGS LKSGCARYCN 730 740 750 760 770 780 ATVKIPKCCK GFYGPDCNQC PGGFSNPCSG NGQCADSLGG NGTCICEEGF QGSQCQFCSD 790 800 810 820 830 840 PNKYGPRCNK KCLCVHGTCN NRIDSDGACL TGTCRDGSAG RLCDKQTSAC GPYVQFCHIH 850 860 870 880 890 900 ATCEYSNGTA SCICKAGYEG DGTLCSEMDP CTGLTPGGCS RNAECIKTGT GTHTCVCQQG 910 920 930 940 950 960 WTGNGRDCSE INNCLLPSAG GCHDNASCLY VGPGQNECEC KKGFRGNGID CEPITSCLEQ 970 980 990 1000 1010 1020 TGKCHPLASC QSTSSGVWSC VCQEGYEGDG FLCYGNAAVE LSFLSEAAIF NRWINNASLQ 1030 1040 1050 1060 1070 1080 PTLSATSNLT VLVPSQQATE DMDQDEKSFW LSQSNIPALI KYHMLLGTYR VADLQTLSSS 1090 1100 1110 1120 1130 1140 DMLATSLQGN FLHLAKVDGN ITIEGASIVD GDNAATNGVI HIINKVLVPQ RRLTGSLPNL 1150 1160 1170 1180 1190 1200 LMRLEQMPDY SIFRGYIIQY NLANAIEAAD AYTVFAPNNN AIENYIREKK VLSLEEDVLR 1210 1220 1230 1240 1250 1260 YHVVLEEKLL KNDLHNGMHR ETMLGFSYFL SFFLHNDQLY VNEAPINYTN VATDKGVIHG 1270 1280 1290 1300 1310 1320 LGKVLEIQKN RCDNNDTTII RGRCRTCSSE LTCPFGTKSL GNEKRRCIYT SYFMGRRTLF 1330 1340 1350 1360 1370 1380 IGCQPKCVRT VITRECCAGF FGPQCQPCPG NAQNVCFGNG ICLDGVNGTG VCECGEGFSG 1390 1400 1410 1420 1430 1440 TACETCTEGK YGIHCDQACS CVHGRCNQGP LGDGSCDCDV GWRGVHCDNA TTEDNCNGTC 1450 1460 1470 1480 1490 1500 HTSANCLTNS DGTASCKCAA GFQGNGTICT AINACEISNG GCSAKADCKR TTPGRRVCTC 1510 1520 1530 1540 1550 1560 KAGYTGDGIV CLEINPCLEN HGGCDKNAEC TQTGPNQAAC NCLPAYTGDG KVCTLINVCL 1570 1580 1590 1600 1610 1620 TKNGGCSEFA ICNHTGQVER TCTCKPNYIG DGFTCRGSIY QELPKNPKTS QYFFQLQEHF 1630 1640 1650 1660 1670 1680 VKDLVGPGPF TVFAPLSAAF DEEARVKDWD KYGLMPQVLR YHVVACHQLL LENLKLISNA 1690 1700 1710 1720 1730 1740 TSLQGEPIVI SVSQSTVYIN NKAKIISSDI ISTNGIVHII DKLLSPKNLL ITPKDNSGRI 1750 1760 1770 1780 1790 1800 LQNLTTLATN NGYIKFSNLI QDSGLLSVIT DPIHTPVTLF WPTDQALHAL PAEQQDFLFN 1810 1820 1830 1840 1850 1860 QDNKDKLKEY LKFHVIRDAK VLAVDLPTST AWKTLQGSEL SVKCGAGRDI GDLFLNGQTC 1870 1880 1890 1900 1910 1920 RIVQRELLFD LGVAYGIDCL LIDPTLGGRC DTFTTFDASG ECGSCVNTPS CPRWSKPKGV 1930 1940 1950 1960 1970 1980 KQKCLYNLPF KRNLEGCRER CSLVIQIPRC CKGYFGRDCQ ACPGGPDAPC NNRGVCLDQY 1990 2000 2010 2020 2030 2040 SATGECKCNT GFNGTACEMC WPGRFGPDCL PCGCSDHGQC DDGITGSGQC LCETGWTGPS 2050 2060 2070 2080 2090 2100 CDTQAVLPAV CTPPCSAHAT CKENNTCECN LDYEGDGITC TVVDFCKQDN GGCAKVARCS 2110 2120 2130 2140 2150 2160 QKGTKVSCSC QKGYKGDGHS CTEIDPCADG LNGGCHEHAT CKMTGPGKHK CECKSHYVGD 2170 2180 2190 2200 2210 2220 GLNCEPEQLP IDRCLQDNGQ CHADAKCVDL HFQDTTVGVF HLRSPLGQYK LTFDKAREAC 2230 2240 2250 2260 2270 2280 ANEAATMATY NQLSYAQKAK YHLCSAGWLE TGRVAYPTAF ASQNCGSGVV GIVDYGPRPN 2290 2300 2310 2320 2330 2340 KSEMWDVFCY RMKDVNCTCK VGYVGDGFSC SGNLLQVLMS FPSLTNFLTE VLAYSNSSAR 2350 2360 2370 2380 2390 2400 GRAFLEHLTD LSIRGTLFVP QNSGLGENET LSGRDIEHHL ANVSMFFYND LVNGTTLQTR 2410 2420 2430 2440 2450 2460 LGSKLLITAS QDPLQPTETR FVDGRAILQW DIFASNGIIH VISRPLKAPP APVTLTHTGL 2470 2480 2490 2500 2510 2520 GAGIFFAIIL VTGAVALAAY SYFRINRRTI GFQHFESEED INVAALGKQQ PENISNPLYE 2530 2540 2550 STTSAPPEPS YDPFTDSEER QLEGNDPLRT L

CATM prediction

The sequence of STAB2_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      2460      2470      248
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 THTGLGAGIFFAIILVTGAVALAAYSY 6.9 -40.0° 5.1 43.9 -28.0
Model 2 THTGLGAGIFFAIILVTGAVALAAYSY 7.0 -48.9° 2.7 63.4 -20.0
Model 3 THTGLGAGIFFAIILVTGAVALAAYSY 6.7 -53.0° 5.2 58.1 -9.8
Model 4 THTGLGAGIFFAIILVTGAVALAAYSY 7.0 -51.0° 2.4 45.0 -2.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 2460, LEU, HA A, 2459, GLY, O 2.66Å
B, 2463, GLY, HA1 A, 2460, LEU, O 3.15Å
A, 2460, LEU, HA B, 2459, GLY, O 2.66Å
A, 2463, GLY, HA1 B, 2460, LEU, O 3.15Å