Potassium voltage-gated channel subfamily E member 4

UniProt data

UniProt name: KCNE4_HUMAN (Q8WWG9)

Gene name: KCNE4

Organism: Homo sapiens (Human).

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 87-107, 21 AA, Helical. {ECO:0000255}.

Sequence: 221 AA

10 20 30 40 50 60 MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA SMLKMEPLNS 70 80 90 100 110 120 THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF LIGIMLGYMK SKRREKKSSL 130 140 150 160 170 180 LLLYKDEERL WGEAMKPLPV VSGLRSVQVP LMLNMLQESV APALSCTLCS MEGDSVSSES 190 200 210 220 SSPDVHLTIQ EEGADDELEE TSETPLNESS EGSSENIHQN S

CATM prediction

The sequence of KCNE4_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        90        100       1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 GNEYFYILVVMSFYGIFLIGIMLGYMK 7.3 -37.9° 0.5 55.9 -20.3
Model 2 GNEYFYILVVMSFYGIFLIGIMLGYMK 7.2 -54.9° 0.9 50.1 -3.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 103, GLY, HA1 A, 100, PHE, O 3.50Å
B, 104, ILE, HA A, 103, GLY, O 3.41Å
A, 103, GLY, HA1 B, 100, PHE, O 3.50Å
A, 104, ILE, HA B, 103, GLY, O 3.41Å