Glycosylated lysosomal membrane protein {ECO:0000312|HGNC:HGNC:29436}

UniProt data

UniProt name: GLMP_HUMAN (Q8WWB7)

Gene name: GLMP {ECO:0000312|HGNC:HGNC:29436}

Organism: Homo sapiens (Human).

Function:

Subcellular location: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:19556463}; Single-pass type I membrane protein {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:19556463}.

Transmembrane domains:

  1. 373-393, 21 AA, Helical. {ECO:0000255}.

Sequence: 406 AA

10 20 30 40 50 60 MRGSVECTWG WGHCAPSPLL LWTLLLFAAP FGLLGEKTRQ VSLEVIPNWL GPLQNLLHIR 70 80 90 100 110 120 AVGTNSTLHY VWSSLGPLAV VMVATNTPHS TLSVNWSLLL SPEPDGGLMV LPKDSIQFSS 130 140 150 160 170 180 ALVFTRLLEF DSTNVSDTAA KPLGRPYPPY SLADFSWNNI TDSLDPATLS ATFQGHPMND 190 200 210 220 230 240 PTRTFANGSL AFRVQAFSRS SRPAQPPRLL HTADTCQLEV ALIGASPRGN RSLFGLEVAT 250 260 270 280 290 300 LGQGPDCPSM QEQHSIDDEY APAVFQLDQL LWGSLPSGFA QWRPVAYSQK PGGRESALPC 310 320 330 340 350 360 QASPLHPALA YSLPQSPIVR AFFGSQNNFC AFNLTFGAST GPGYWDQHYL SWSMLLGVGF 370 380 390 400 PPVDGLSPLV LGIMAVALGA PGLMLLGGGL VLLLHHKKYS EYQSIN

CATM prediction

The sequence of GLMP_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  370       380       390    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 VLGIMAVALGAAGLMLLGGGLVLLLHH 7.1 -53.1° 1.9 45.5 -38.2
Model 2 VLGIMAVALGAAGLMLLGGGLVLLLHH 7.4 -53.9° 3.6 48.9 -5.5
Model 3 VLGIMAVALGAAGLMLLGGGLVLLLHH 7.4 -54.2° 3.6 49.0 -2.6
Prolines* VLGIMAVALGAPGLMLLGGGLVLLLHH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 384, MET, HA A, 383, LEU, O 3.15Å
B, 387, GLY, HA1 A, 384, MET, O 2.82Å
A, 384, MET, HA B, 383, LEU, O 3.15Å
A, 387, GLY, HA1 B, 384, MET, O 2.82Å