Leucine-rich repeat neuronal protein 4

UniProt data

UniProt name: LRRN4_HUMAN (Q8WUT4)

Gene name: LRRN4; Synonyms=C20orf75

Organism: Homo sapiens (Human).

Function: May play an important role in hippocampus-dependent long-lasting memory. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 680-700, 21 AA, Helical. {ECO:0000255}.

Sequence: 740 AA

10 20 30 40 50 60 MRQTLPLLLL TVLRPSWADP PQEKVPLFRV TQQGPWGSSG SNATDSPCEG LPAADATALT 70 80 90 100 110 120 LANRNLERLP GCLPRTLRSL DASHNLLRAL STSELGHLEQ LQVLTLRHNR IAALRWGPGG 130 140 150 160 170 180 PAGLHTLDLS YNQLAALPPC TGPALSSLRA LALAGNPLRA LQPRAFACFP ALQLLNLSCT 190 200 210 220 230 240 ALGRGAQGGI AEAAFAGEDG APLVTLEVLD LSGTFLERVE SGWIRDLPKL TSLYLRKMPR 250 260 270 280 290 300 LTTLEGDIFK MTPNLQQLDC QDSPALASVA THIFQDTPHL QVLLFQNCNL SSFPPWTLDS 310 320 330 340 350 360 SQVLSINLFG NPLTCSCDLS WLLTDAKRTV LSRAADTMCA PAAGSSGPFS ASLSLSQLPG 370 380 390 400 410 420 VCQSDQSTTL GASHPPCFNR STYAQGTTVA PSAAPATRPA GDQQSVSKAP NVGSRTIAAW 430 440 450 460 470 480 PHSDAREGTA PSTTNSVAGH SNSSVFPRAA STTRTQHRGE HAPELVLEPD ISAASTPLAS 490 500 510 520 530 540 KLLGPFPTSW DRSISSPQPG QRTHATPQAP NPSLSEGEIP VLLLDDYSEE EEGRKEEVGT 550 560 570 580 590 600 PHQDVPCDYH PCKHLQTPCA ELQRRWRCRC PGLSGEDTIP DPPRLQGVTE TTDTSALVHW 610 620 630 640 650 660 CAPNSVVHGY QIRYSAEGWA GNQSVVGVIY ATARQHPLYG LSPGTTYRVC VLAANRAGLS 670 680 690 700 710 720 QPRSSGWRSP CAAFTTKPSF ALLLSGLCAA SGLLLASTVV LSACLCRRGQ TLGLQRCDTH 730 LVAYKNPAFD DYPLGLQTVS

CATM prediction

The sequence of LRRN4_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     680       690       700 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 KASFALLLSGLCAASGLLLASTVVLSA 6.9 -46.1° 2.7 46.9 -15.7
Model 2 KASFALLLSGLCAASGLLLASTVVLSA 7.3 -51.1° 2.4 44.8 -10.7
Prolines* KPSFALLLSGLCAASGLLLASTVVLSA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 689, ALA, HA A, 688, CYS, O 2.97Å
B, 692, GLY, HA1 A, 689, ALA, O 2.91Å
B, 693, LEU, HA A, 692, GLY, O 3.48Å
A, 689, ALA, HA B, 688, CYS, O 2.97Å
A, 692, GLY, HA1 B, 689, ALA, O 2.91Å
A, 693, LEU, HA B, 692, GLY, O 3.48Å