Phospholipase ABHD3 {ECO:0000305}

UniProt data

UniProt name: ABHD3_HUMAN (Q8WU67)

Gene name: ABHD3 {ECO:0000312|HGNC:HGNC:18718}

Organism: Homo sapiens (Human).

Function: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain- containing and oxidatively truncated phospholipids. {ECO:0000269|PubMed:21926997}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 26-46, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 409 AA

10 20 30 40 50 60 MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS SIAKKPQLVT 70 80 90 100 110 120 GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT SKPPVQYRNE LIKTADGGQI 130 140 150 160 170 180 SLDWFDNDNS TCYMDASTRP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA 190 200 210 220 230 240 GENLLTPRTY CCANTEDLET VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM 250 260 270 280 290 300 AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS 310 320 330 340 350 360 IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP SHAIPIETAK 370 380 390 400 QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELS

CATM prediction

The sequence of ABHD3_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         30        40        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 VRVGFFGSGVGLSLILGFSVAYAFYYL 7.4 -44.0° 0.9 46.0 -24.2
Model 2 VRVGFFGSGVGLSLILGFSVAYAFYYL 7.4 -43.0° 3.4 50.1 -22.0
Model 3 VRVGFFGSGVGLSLILGFSVAYAFYYL 6.7 -47.0° 1.4 45.0 -20.9
Model 4 VRVGFFGSGVGLSLILGFSVAYAFYYL 6.8 -47.8° 3.3 34.3 -15.8
Model 5 VRVGFFGSGVGLSLILGFSVAYAFYYL 7.2 -55.0° 0.9 50.3 -15.3
Model 6 VRVGFFGSGVGLSLILGFSVAYAFYYL 6.9 -55.0° 4.2 38.0 -3.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 31, GLY, HA1 A, 28, PHE, O 3.39Å
B, 32, VAL, HA A, 31, GLY, O 3.45Å
B, 35, SER, HG1 A, 32, VAL, O 2.44Å
A, 31, GLY, HA1 B, 28, PHE, O 3.39Å
A, 32, VAL, HA B, 31, GLY, O 3.45Å
A, 35, SER, HG1 B, 32, VAL, O 2.44Å