Nuclear pore membrane glycoprotein 210

UniProt data

UniProt name: PO210_HUMAN (Q8TEM1)

Gene name: NUP210; Synonyms=KIAA0906; ORFNames=PSEC0245

Organism: Homo sapiens (Human).

Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}.

Subcellular location: Nucleus, nuclear pore complex {ECO:0000269|PubMed:2195063}. Nucleus membrane {ECO:0000269|PubMed:2195063}; Single-pass type I membrane protein {ECO:0000269|PubMed:2195063}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2195063}; Single-pass type I membrane protein {ECO:0000269|PubMed:2195063}.

Transmembrane domains:

  1. 1809-1829, 21 AA, Helical. {ECO:0000255}.

Sequence: 1887 AA

10 20 30 40 50 60 MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR 70 80 90 100 110 120 PEVASIEPLG LDEQQCSQKA VVQARLTQPA RLTSIIFAED ITTGQVLRCD AIVDLIHDIQ 130 140 150 160 170 180 IVSTTRELYL EDSPLELKIQ ALDSEGNTFS TLAGLVFEWT IVKDSEADRF SDSHNALRIL 190 200 210 220 230 240 TFLESTYIPP SYISEMEKAA KQGDTILVSG MKTGSSKLKA RIQEAVYKNV RPAEVRLLIL 250 260 270 280 290 300 ENILLNPAYD VYLMVGTSIH YKVQKIRQGK ITELSMPSDQ YELQLQNSIP GPEGDPARPV 310 320 330 340 350 360 AVLAQDTSMV TALQLGQSSL VLGHRSIRMQ GASRLPNSTI YVVEPGYLGF TVHPGDRWVL 370 380 390 400 410 420 ETGRLYEITI EVFDKFSNKV YVSDNIRIET VLPAEFFEVL SSSQNGSYHR IRALKRGQTA 430 440 450 460 470 480 IDAALTSVVD QDGGVHILQV PVWNQQEVEI HIPITLYPSI LTFPWQPKTG AYQYTIRAHG 490 500 510 520 530 540 GSGNFSWSSS SHLVATVTVK GVMTTGSDIG FSVIQAHDVQ NPLHFGEMKV YVIEPHSMEF 550 560 570 580 590 600 APCQVEARVG QALELPLRIS GLMPGGASEV VTLSDCSHFD LAVEVENQGV FQPLPGRLPP 610 620 630 640 650 660 GSEHCSGIRV KAEAQGSTTL LVSYRHGHVH LSAKITIAAY LPLKAVDPSS VALVTLGSSK 670 680 690 700 710 720 EMLFEGGPRP WILEPSKFFQ NVTAEDTDSI GLALFAPHSS RNYQQHWILV TCQALGEQVI 730 740 750 760 770 780 ALSVGNKPSL TNPFPAVEPA VVKFVCAPPS RLTLAPVYTS PQLDMSCPLL QQNKQVVPVS 790 800 810 820 830 840 SHRNPRLDLA AYDQEGRRFD NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH 850 860 870 880 890 900 GLQAILVHEA SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIELI LVEDVRVSPE 910 920 930 940 950 960 EVTIYNHPGI QAELRIREGS GYFFLNTSTA DVVKVAYQEA RGVAMVHPLL PGSSTIMIHD 970 980 990 1000 1010 1020 LCLVFPAPAK AVVYVSDIQE LYIRVVDKVE IGKTVKAYVR VLDLHKKPFL AKYFPFMDLK 1030 1040 1050 1060 1070 1080 LRAASPIITL VALDEALDNY TITFLIRGVA IGQTSLTASV TNKAGQRINS APQQIEVFPP 1090 1100 1110 1120 1130 1140 FRLMPRKVTL LIGATMQVTS EGGPQPQSNI LFSISNESVA LVSAAGLVQG LAIGNGTVSG 1150 1160 1170 1180 1190 1200 LVQAVDAETG KVVIISQDLV QVEVLLLRAV RIRAPIMRMR TGTQMPIYVT GITNHQNPFS 1210 1220 1230 1240 1250 1260 FGNAVPGLTF HWSVTKRDVL DLRGRHHEAS IRLPSQYNFA MNVLGRVKGR TGLRVVVKAV 1270 1280 1290 1300 1310 1320 DPTSGQLYGL ARELSDEIQV QVFEKLQLLN PEIEAEQILM SPNSYIKLQT NRDGAASLSY 1330 1340 1350 1360 1370 1380 RVLDGPEKVP VVHVDEKGFL ASGSMIGTST IEVIAQEPFG ANQTIIVAVK VSPVSYLRVS 1390 1400 1410 1420 1430 1440 MSPVLHTQNK EALVAVPLGM TVTFTVHFHD NSGDVFHAHS SVLNFATNRD DFVQIGKGPT 1450 1460 1470 1480 1490 1500 NNTCVVRTVS VGLTLLRVWD AEHPGLSDFM PLPVLQAISP ELSGAMVVGD VLCLATVLTS 1510 1520 1530 1540 1550 1560 LEGLSGTWSS SANSILHIDP KTGVAVARAV GSVTVYYEVA GHLRTYKEVV VSVPQRIMAR 1570 1580 1590 1600 1610 1620 HLHPIQTSFQ EATASKVIVA VGDRSSNLRG ECTPTQREVI QALHPETLIS CQSQFKPAVF 1630 1640 1650 1660 1670 1680 DFPSQDVFTV EPQFDTALGQ YFCSITMHRL TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ 1690 1700 1710 1720 1730 1740 VGAEVPFSPG LFADQAEILL SNHYTSSEIR VFGAPEVLEN LEVKSGSPAV LAFAKEKSFG 1750 1760 1770 1780 1790 1800 WPSFITYTVG VLDPAAGSQG PLSTTLTFSS PVTNQAIAIP VTVAFVVDRR GPGPYGASLF 1810 1820 1830 1840 1850 1860 QHFLDSYQVM FFTLFALLAG TAVMIIAYHT VCTPRDLAVP AALTPRASPG HSPHYFAASS 1870 1880 PTSPNALPPA RKASPPSGLW SPAYASH

CATM prediction

The sequence of PO210_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      1810      1820      183
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 SYQVMFFTLFALLAGTAVMIIAYHTVC 7.1 -37.9° 5.7 34.0 -26.6
Model 2 SYQVMFFTLFALLAGTAVMIIAYHTVC 7.1 -55.0° 2.4 48.0 -24.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1817, LEU, HA A, 1816, ALA, O 3.08Å
B, 1820, GLY, HA1 A, 1817, LEU, O 3.43Å
B, 1825, ILE, HA A, 1828, TYR, OH 2.57Å
A, 1817, LEU, HA B, 1816, ALA, O 3.08Å
A, 1820, GLY, HA1 B, 1817, LEU, O 3.43Å