UniProt data
UniProt name: IGDC4_HUMAN (Q8TDY8)
Gene name: IGDCC4; Synonyms=DDM36, KIAA1628, NOPE
Organism: Homo sapiens (Human).
Function:
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 958-978, 21 AA, Helical. {ECO:0000255}.
Sequence: 1250 AA
10 20 30 40 50 60
MARGDAGRGR GLLALTFCLL AARGELLLPQ ETTVELSCGV GPLQVILGPE QAAVLNCSLG
70 80 90 100 110 120
AAAAGPPTRV TWSKDGDTLL EHDHLHLLPN GSLWLSQPLA PNGSDESVPE AVGVIEGNYS
130 140 150 160 170 180
CLAHGPLGVL ASQTAVVKLA TLADFSLHPE SQTVEENGTA RFECHIEGLP APIITWEKDQ
190 200 210 220 230 240
VTLPEEPRLI VLPNGVLQIL DVQESDAGPY RCVATNSARQ HFSQEALLSV AHRGSLASTR
250 260 270 280 290 300
GQDVVIVAAP ENTTVVSGQS VVMECVASAD PTPFVSWVRQ DGKPISTDVI VLGRTNLLIA
310 320 330 340 350 360
NAQPWHSGVY VCRANKPRTR DFATAAAELR VLAAPAITQA PEALSRTRAS TARFVCRASG
370 380 390 400 410 420
EPRPALRWLH NGAPLRPNGR VKVQGGGGSL VITQIGLQDA GYYQCVAENS AGMACAAASL
430 440 450 460 470 480
AVVVREGLPS APTRVTATPL SSSAVLVAWE RPEMHSEQII GFSLHYQKAR GMDNVEYQFA
490 500 510 520 530 540
VNNDTTELQV RDLEPNTDYE FYVVAYSQLG ASRTSTPALV HTLDDVPSAA PQLSLSSPNP
550 560 570 580 590 600
SDIRVAWLPL PPSLSNGQVV KYKIEYGLGK EDQIFSTEVR GNETQLMLNS LQPNKVYRVR
610 620 630 640 650 660
ISAGTAAGFG APSQWMHHRT PSMHNQSHVP FAPAELKVQA KMESLVVSWQ PPPHPTQISG
670 680 690 700 710 720
YKLYWREVGA EEEANGDRLP GGRGDQAWDV GPVRLKKKVK QYELTQLVPG RLYEVKLVAF
730 740 750 760 770 780
NKHEDGYAAV WKGKTEKAPA PDMPIQRGPP LPPAHVHAES NSSTSIWLRW KKPDFTTVKI
790 800 810 820 830 840
VNYTVRFSPW GLRNASLVTY YTSSGEDILI GGLKPFTKYE FAVQSHGVDM DGPFGSVVER
850 860 870 880 890 900
STLPDRPSTP PSDLRLSPLT PSTVRLHWCP PTEPNGEIVE YLILYSSNHT QPEHQWTLLT
910 920 930 940 950 960
TQGNIFSAEV HGLESDTRYF FKMGARTEVG PGPFSRLQDV ITLQEKLSDS LDMHSVTGII
970 980 990 1000 1010 1020
VGVCLGLLCL LACMCAGLRR SPHRESLPGL SSTATPGNPA LYSRARLGPP SPPAAHELES
1030 1040 1050 1060 1070 1080
LVHPHPQDWS PPPSDVEDRA EVHSLMGGGV SEGRSHSKRK ISWAQPSGLS WAGSWAGCEL
1090 1100 1110 1120 1130 1140
PQAGPRPALT RALLPPAGTG QTLLLQALVY DAIKGNGRKK SPPACRNQVE AEVIVHSDFS
1150 1160 1170 1180 1190 1200
ASNGNPDLHL QDLEPEDPLP PEAPDLISGV GDPGQGAAWL DRELGGCELA APGPDRLTCL
1210 1220 1230 1240
PEAASASCSY PDLQPGEVLE ETPGDSCQLK SPCPLGASPG LPRSPVSSSA
CATM prediction
The sequence of IGDC4_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 960 970 98 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | SVTGIIVGVCLGLLCLLACMCAGLRRS | 6.5 | -35.1° | 3.8 | 52.6 | -29.1 |
| Model 2 | SVTGIIVGVCLGLLCLLACMCAGLRRS | 6.6 | -48.9° | 2.7 | 63.3 | -21.7 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 959, ILE, HA | A, 958, GLY, O | 2.26Å |
| B, 962, GLY, HA1 | A, 959, ILE, O | 2.73Å |
| B, 963, VAL, HA | A, 962, GLY, O | 3.15Å |
| A, 959, ILE, HA | B, 958, GLY, O | 2.26Å |
| A, 962, GLY, HA1 | B, 959, ILE, O | 2.73Å |
| A, 963, VAL, HA | B, 962, GLY, O | 3.15Å |
