Neuropilin and tolloid-like protein 1

UniProt data

UniProt name: NETO1_HUMAN (Q8TDF5)

Gene name: NETO1; Synonyms=BTCL1

Organism: Homo sapiens (Human).

Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). {ECO:0000250}.

Subcellular location: Isoform 1: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 345-365, 21 AA, Helical. {ECO:0000255}.

Sequence: 533 AA

10 20 30 40 50 60 MIHGRSVLHI VASLIILHLS GATKKGTEKQ TTSETQKSVQ CGTWTKHAEG GIFTSPNYPS 70 80 90 100 110 120 KYPPDRECIY IIEAAPRQCI ELYFDEKYSI EPSWECKFDH IEVRDGPFGF SPIIGRFCGQ 130 140 150 160 170 180 QNPPVIKSSG RFLWIKFFAD GELESMGFSA RYNFTPDPDF KDLGALKPLP ACEFEMGGSE 190 200 210 220 230 240 GIVESIQIMK EGKATASEAV DCKWYIRAPP RSKIYLRFLD YEMQNSNECK RNFVAVYDGS 250 260 270 280 290 300 SSVEDLKAKF CSTVANDVML RTGLGVIRMW ADEGSRNSRF QMLFTSFQEP PCEGNTFFCH 310 320 330 340 350 360 SNMCINNTLV CNGLQNCVYP WDENHCKEKR KTSLLDQLTN TSGTVIGVTS CIVIILIIIS 370 380 390 400 410 420 VIVQIKQPRK KYVQRKSDFD QTVFQEVFEP PHYELCTLRG TGATADFADV ADDFENYHKL 430 440 450 460 470 480 RRSSSKCIHD HHCGSQLSST KGSRSNLSTR DASILTEMPT QPGKPLIPPM NRRNILVMKH 490 500 510 520 530 SYSQDAADAC DIDEIEEVPT TSHRLSRHDK AVQRFCLIGS LSKHESEYNT TRV

CATM prediction

The sequence of NETO1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          350       360      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 SGTVIGVTSCIVIILIIISVIVQIKQA 7.4 -41.0° 3.5 38.0 -13.3
Model 2 SGTVIGVTSCIVIILIIISVIVQIKQA 6.6 -51.0° 4.8 57.0 -3.6
Prolines* SGTVIGVTSCIVIILIIISVIVQIKQP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session