Protein MGARP

UniProt data

UniProt name: HUMMR_HUMAN (Q8TDB4)

Gene name: MGARP; Synonyms=C4orf49, CESP1, HUMMR, OSAP; ORFNames=GS3582

Organism: Homo sapiens (Human).

Function: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). {ECO:0000250}.

Subcellular location: Mitochondrion {ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:21447634}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250|UniProtKB:Q8VI64}.

Transmembrane domains:

  1. 41-63, 23 AA, Helical; Anchor for type IV membrane protein. {ECO:0000250}.

Sequence: 240 AA

10 20 30 40 50 60 MYLRRAVSKT LALPLRAPPN PAPLGKDASL RRMSSNRFPG SSGSNMIYYL VVGVTVSAGG 70 80 90 100 110 120 YYAYKTVTSD QAKHTEHKTN LKEKTKAEIH PFQGEKENVA ETEKASSEAP EELIVEAEVV 130 140 150 160 170 180 DAEESPSATV VVIKEASACP GHVEAAPETT AVSAETGPEV TDAAARETTE VNPETTPEVT 190 200 210 220 230 NAALDEAVTI DNDKDTTKNE TSDEYAELEE ENSPAESESS AGDDLQEEAS VGSEAASAQG

CATM prediction

The sequence of HUMMR_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    40        50        60     
  |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 FAGSSGSNMIYYLVVGVTVSAGGYYAYKT 7.2 -49.0° 1.8 45.1 -13.9
Model 2 FAGSSGSNMIYYLVVGVTVSAGGYYAYKT 7.4 -41.4° 0.6 43.2 -5.1
Model 3 FAGSSGSNMIYYLVVGVTVSAGGYYAYKT 7.3 -35.0° 5.0 34.9 -3.7
Prolines* FPGSSGSNMIYYLVVGVTVSAGGYYAYKT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 53, GLY, HA1 A, 50, LEU, O 3.20Å
B, 54, VAL, HA A, 53, GLY, O 3.33Å
B, 57, SER, HG1 A, 54, VAL, O 2.51Å
B, 58, ALA, HA A, 61, TYR, OH 2.75Å
A, 53, GLY, HA1 B, 50, LEU, O 3.20Å
A, 54, VAL, HA B, 53, GLY, O 3.33Å
A, 57, SER, HG1 B, 54, VAL, O 2.51Å
A, 58, ALA, HA B, 61, TYR, OH 2.95Å