CD99 antigen-like protein 2

UniProt data

UniProt name: C99L2_HUMAN (Q8TCZ2)

Gene name: CD99L2; Synonyms=MIC2L1; ORFNames=UNQ1964/PRO4486

Organism: Homo sapiens (Human).

Function: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250}.

Transmembrane domains:

  1. 186-206, 21 AA, Helical. {ECO:0000255}.

Sequence: 262 AA

10 20 30 40 50 60 MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT TTTTNRPGTT 70 80 90 100 110 120 RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRERWNHVTT TTKRPVTTRA PANTLGNDFD 130 140 150 160 170 180 LADALDDRND RDDGRRKPIA GGGGFSDKDL EDIVGGGEYK PDKGKGDGRY GSNDDPGSGM 190 200 210 220 230 240 VAEPGTIAGV ASALAMALIG AVSSYISYQQ KKFCFSIQQG LNADYVKGEN LEAVVCEEPQ 250 260 VKYSTLHTQS AEPPPPPEPA RI

CATM prediction

The sequence of C99L2_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         190       200       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 EAGTIAGVASALAMALIGAVSSYISYQ 6.5 -53.0° 3.1 34.0 -23.8
Model 2 EAGTIAGVASALAMALIGAVSSYISYQ 7.2 -36.0° 3.6 36.0 -19.4
Model 3 EAGTIAGVASALAMALIGAVSSYISYQ 6.4 -52.8° 2.3 61.8 -12.3
Model 4 EAGTIAGVASALAMALIGAVSSYISYQ 7.2 -37.0° 2.3 35.9 -6.1
Model 5 EAGTIAGVASALAMALIGAVSSYISYQ 7.4 -36.0° 3.6 35.9 -5.8
Prolines* EPGTIAGVASALAMALIGAVSSYISYQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 197, ALA, HA A, 196, MET, O 2.82Å
B, 200, GLY, HA1 A, 197, ALA, O 2.59Å
B, 201, ALA, HA A, 204, SER, OG 3.10Å
A, 197, ALA, HA B, 196, MET, O 2.82Å
A, 200, GLY, HA1 B, 197, ALA, O 2.59Å
A, 201, ALA, HA B, 204, SER, OG 3.10Å