Disintegrin and metalloproteinase domain-containing protein 32

UniProt data

UniProt name: ADA32_HUMAN (Q8TC27)

Gene name: ADAM32; ORFNames=UNQ5982/PRO21340

Organism: Homo sapiens (Human).

Function: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 683-703, 21 AA, Helical. {ECO:0000255}.

Sequence: 787 AA

10 20 30 40 50 60 MFRLWLLLAG LCGLLASRPG FQNSLLQIVI PEKIQTNTND SSEIEYEQIS YIIPIDEKLY 70 80 90 100 110 120 TVHLKQRYFL ADNFMIYLYN QGSMNTYSSD IQTQCYYQGN IEGYPDSMVT LSTCSGLRGI 130 140 150 160 170 180 LQFENVSYGI EPLESAVEFQ HVLYKLKNED NDIAIFIDRS LKEQPMDDNI FISEKSEPAV 190 200 210 220 230 240 PDLFPLYLEM HIVVDKTLYD YWGSDSMIVT NKVIEIVGLA NSMFTQFKVT IVLSSLELWS 250 260 270 280 290 300 DENKISTVGE ADELLQKFLE WKQSYLNLRP HDIAYLLIYM DYPRYLGAVF PGTMCITRYS 310 320 330 340 350 360 AGVALYPKEI TLEAFAVIVT QMLALSLGIS YDDPKKCQCS ESTCIMNPEV VQSNGVKTFS 370 380 390 400 410 420 SCSLRSFQNF ISNVGVKCLQ NKPQMQKKSP KPVCGNGRLE GNEICDCGTE AQCGPASCCD 430 440 450 460 470 480 FRTCVLKDGA KCYKGLCCKD CQILQSGVEC RPKAHPECDI AENCNGTSPE CGPDITLING 490 500 510 520 530 540 LSCKNNKFIC YDGDCHDLDA RCESVFGKGS RNAPFACYEE IQSQSDRFGN CGRDRNNKYV 550 560 570 580 590 600 FCGWRNLICG RLVCTYPTRK PFHQENGDVI YAFVRDSVCI TVDYKLPRTV PDPLAVKNGS 610 620 630 640 650 660 QCDIGRVCVN RECVESRIIK ASAHVCSQQC SGHGVCDSRN KCHCSPGYKP PNCQIRSKGF 670 680 690 700 710 720 SIFPEEDMGS IMERASGKTE NTWLLGFLIA LPILIVTTAI VLARKQLKKW FAKEEEFPSS 730 740 750 760 770 780 ESKSEGSTQT YASQSSSEGS TQTYASQTRS ESSSQADTSK SKSEDSAEAY TSRSKSQDST QTQSSSN

CATM prediction

The sequence of ADA32_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  680       690       700    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ENTWLLGFLIALAILIVTTAIVLARKQ 7.4 -42.0° 2.9 50.0 -6.8
Prolines* ENTWLLGFLIALPILIVTTAIVLARKQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 686, GLY, HA1 A, 683, TRP, O 3.45Å
A, 686, GLY, HA1 B, 683, TRP, O 3.45Å