T-cell immunomodulatory protein

UniProt data

UniProt name: TIP_HUMAN (Q8TB96)

Gene name: ITFG1 {ECO:0000312|HGNC:HGNC:30697}

Organism: Homo sapiens (Human).

Function: Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). {ECO:0000250}.

Subcellular location: Secreted {ECO:0000305}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 567-587, 21 AA, Helical. {ECO:0000255}.

Sequence: 612 AA

10 20 30 40 50 60 MAAAGRLPSS WALFSPLLAG LALLGVGPVP ARALHNVTAE LFGAEAWGTL AAFGDLNSDK 70 80 90 100 110 120 QTDLFVLRER NDLIVFLADQ NAPYFKPKVK VSFKNHSALI TSVVPGDYDG DSQMDVLLTY 130 140 150 160 170 180 LPKNYAKSEL GAVIFWGQNQ TLDPNNMTIL NRTFQDEPLI MDFNGDLIPD IFGITNESNQ 190 200 210 220 230 240 PQILLGGNLS WHPALTTTSK MRIPHSHAFI DLTEDFTADL FLTTLNATTS TFQFEIWENL 250 260 270 280 290 300 DGNFSVSTIL EKPQNMMVVG QSAFADFDGD GHMDHLLPGC EDKNCQKSTI YLVRSGMKQW 310 320 330 340 350 360 VPVLQDFSNK GTLWGFVPFV DEQQPTEIPI PITLHIGDYN MDGYPDALVI LKNTSGSNQQ 370 380 390 400 410 420 AFLLENVPCN NASCEEARRM FKVYWELTDL NQIKDAMVAT FFDIYEDGIL DIVVLSKGYT 430 440 450 460 470 480 KNDFAIHTLK NNFEADAYFV KVIVLSGLCS NDCPRKITPF GVNQPGPYIM YTTVDANGYL 490 500 510 520 530 540 KNGSAGQLSQ SAHLALQLPY NVLGLGRSAN FLDHLYVGIP RPSGEKSIRK QEWTAIIPNS 550 560 570 580 590 600 QLIVIPYPHN VPRSWSAKLY LTPSNIVLLT AIALIGVCVF ILAIIGILHW QEKKADDREK 610 RQEAHRFHFD AM

CATM prediction

The sequence of TIP_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        570       580       5
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 SNIVLLTAIALIGVCVFILAIIGILHW 7.4 -54.0° 3.6 35.0 -11.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 573, ALA, HA A, 572, ILE, O 3.45Å
B, 576, GLY, HA1 A, 573, ALA, O 3.46Å
A, 573, ALA, HA B, 572, ILE, O 3.45Å
A, 576, GLY, HA1 B, 573, ALA, O 3.46Å