Interleukin-31 receptor subunit alpha

UniProt data

UniProt name: IL31R_HUMAN (Q8NI17)

Gene name: IL31RA; Synonyms=CRL3, GPL; ORFNames=UNQ6368/PRO21073/PRO21384

Organism: Homo sapiens (Human).

Function: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity). {ECO:0000250|UniProtKB:Q8K5B1, ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15627637}.

Subcellular location: Cell membrane {ECO:0000305|PubMed:11877449, ECO:0000305|PubMed:14504285}; Single-pass type I membrane protein {ECO:0000305|PubMed:11877449, ECO:0000305|PubMed:14504285}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:Q8K5B1}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K5B1}.

Transmembrane domains:

  1. 520-540, 21 AA, Helical. {ECO:0000255}.

Sequence: 732 AA

10 20 30 40 50 60 MMWTWALWML PSLCKFSLAA LPAKPENISC VYYYRKNLTC TWSPGKETSY TQYTVKRTYA 70 80 90 100 110 120 FGEKHDNCTT NSSTSENRAS CSFFLPRITI PDNYTIEVEA ENGDGVIKSH MTYWRLENIA 130 140 150 160 170 180 KTEPPKIFRV KPVLGIKRMI QIEWIKPELA PVSSDLKYTL RFRTVNSTSW MEVNFAKNRK 190 200 210 220 230 240 DKNQTYNLTG LQPFTEYVIA LRCAVKESKF WSDWSQEKMG MTEEEAPCGL ELWRVLKPAE 250 260 270 280 290 300 ADGRRPVRLL WKKARGAPVL EKTLGYNIWY YPESNTNLTE TMNTTNQQLE LHLGGESFWV 310 320 330 340 350 360 SMISYNSLGK SPVATLRIPA IQEKSFQCIE VMQACVAEDQ LVVKWQSSAL DVNTWMIEWF 370 380 390 400 410 420 PDVDSEPTTL SWESVSQATN WTIQQDKLKP FWCYNISVYP MLHDKVGEPY SIQAYAKEGV 430 440 450 460 470 480 PSEGPETKVE NIGVKTVTIT WKEIPKSERK GIICNYTIFY QAEGGKGFSK TVNSSILQYG 490 500 510 520 530 540 LESLKRKTSY IVQVMASTSA GGTNGTSINF KTLSFSVFEI ILITSLIGGG LLILIILTVA 550 560 570 580 590 600 YGLKKPNKLT HLCWPTVPNP AESSIATWHG DDFKDKLNLK ESDDSVNTED RILKPCSTPS 610 620 630 640 650 660 DKLVIDKLVV NFGNVLQEIF TDEARTGQEN NLGGEKNGYV TCPFRPDCPL GKSFEELPVS 670 680 690 700 710 720 PEIPPRKSQY LRSRMPEGTR PEAKEQLLFS GQSLVPDHLC EEGAPNPYLK NSVTAREFLV 730 SEKLPEHTKG EV

CATM prediction

The sequence of IL31R_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     520       530       540 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 VFEIILITSLIGGGLLILIILTVAYGL 7.3 -54.7° 2.4 47.9 -9.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 526, LEU, HA A, 525, SER, O 3.46Å
B, 529, GLY, HA1 A, 526, LEU, O 3.23Å
A, 526, LEU, HA B, 525, SER, O 3.46Å
A, 529, GLY, HA1 B, 526, LEU, O 3.23Å