Beta-1,4 N-acetylgalactosaminyltransferase 2

UniProt data

UniProt name: B4GN2_HUMAN (Q8NHY0)

Gene name: B4GALNT2; Synonyms=GALGT2

Organism: Homo sapiens (Human).

Function: Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. {ECO:0000269|PubMed:12678917, ECO:0000269|PubMed:14688233}.

Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 68-88, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 566 AA

10 20 30 40 50 60 MGSAGFSVGK FHVEVASRGR ECVSGTPECG NRLGSAGFGA LCLELRGADP AWGPFAAHGR 70 80 90 100 110 120 SRRQGSRFLW LLKILVIILV LGIVGFMFGS MFLQAVFSSP KPELPSPAPG VQKLKLLPEE 130 140 150 160 170 180 RLRNLFSYDG IWLFPKNQCK CEANKEQGGY NFQDAYGQSD LPAVKARRQA EFEHFQRREG 190 200 210 220 230 240 LPRPLPLLVQ PNLPFGYPVH GVEVMPLHTV PIPGLQFEGP DAPVYEVTLT ASLGTLNTLA 250 260 270 280 290 300 DVPDSVVQGR GQKQLIISTS DRKLLKFILQ HVTYTSTGYQ HQKVDIVSLE SRSSVAKFPV 310 320 330 340 350 360 TIRHPVIPKL YDPGPERKLR NLVTIATKTF LRPHKLMIML RSIREYYPDL TVIVADDSQK 370 380 390 400 410 420 PLEIKDNHVE YYTMPFGKGW FAGRNLAISQ VTTKYVLWVD DDFLFNEETK IEVLVDVLEK 430 440 450 460 470 480 TELDVVGGSV LGNVFQFKLL LEQSENGACL HKRMGFFQPL DGFPSCVVTS GVVNFFLAHT 490 500 510 520 530 540 ERLQRVGFDP RLQRVAHSEF FIDGLGTLLV GSCPEVIIGH QSRSPVVDSE LAALEKTYNT 550 560 YRSNTLTRVQ FKLALHYFKN HLQCAA

CATM prediction

The sequence of B4GN2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       70        80        90
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 GSRFLWLLKILVIILVLGIVGFMFGSM 7.2 -48.1° 0.7 54.1 -17.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 85, GLY, HA1 A, 82, GLY, O 3.37Å
B, 86, PHE, HA A, 85, GLY, O 3.32Å
A, 85, GLY, HA1 B, 82, GLY, O 3.37Å
A, 86, PHE, HA B, 85, GLY, O 3.32Å