Leukocyte immunoglobulin-like receptor subfamily B member 1

UniProt data

UniProt name: LIRB1_HUMAN (Q8NHL6)

Gene name: LILRB1; Synonyms=ILT2, LIR1, MIR7

Organism: Homo sapiens (Human).

Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.

Subcellular location: Isoform 5: Secreted {ECO:0000269|PubMed:19658091}.

Transmembrane domains:

  1. 462-482, 21 AA, Helical. {ECO:0000255}.

Sequence: 650 AA

10 20 30 40 50 60 MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL 70 80 90 100 110 120 YREKKTALWI TRIPQELVKK GQFPIPSITW EHAGRYRCYY GSDTAGRSES SDPLELVVTG 130 140 150 160 170 180 AYIKPTLSAQ PSPVVNSGGN VILQCDSQVA FDGFSLCKEG EDEHPQCLNS QPHARGSSRA 190 200 210 220 230 240 IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE 250 260 270 280 290 300 TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA 310 320 330 340 350 360 HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE 370 380 390 400 410 420 GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS 430 440 450 460 470 480 GPSGGPSSPT TGPTSTSGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVI LLLLLLLLLF 490 500 510 520 530 540 LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKHTQ 550 560 570 580 590 600 PEDGVEMDTR SPHDEDPQAV TYAEVKHSRP RREMASPPSP LSGEFLDTKD RQAEEDRQMD 610 620 630 640 TEAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEGPSPAV PSIYATLAIH

CATM prediction

The sequence of LIRB1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   460       470       480   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 LGVVIGILVAVILLLLLLLLLFLILRH 6.5 -47.0° 3.3 54.0 -16.6

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MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session