Cell adhesion molecule 4

UniProt data

UniProt name: CADM4_HUMAN (Q8NFZ8)

Gene name: CADM4; Synonyms=IGSF4C, NECL4, TSLL2

Organism: Homo sapiens (Human).

Function: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity. {ECO:0000269|PubMed:16261159}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 325-345, 21 AA, Helical. {ECO:0000255}.

Sequence: 388 AA

10 20 30 40 50 60 MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD GSIVVIQNPA 70 80 90 100 110 120 RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG GYFCQLYTED THHQIATLTV 130 140 150 160 170 180 LVAPENPVVE VREQAVEGGE VELSCLVPRS RPAATLRWYR DRKELKGVSS SQENGKVWSV 190 200 210 220 230 240 ASTVRFRVDR KDDGGIIICE AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT 250 260 270 280 290 300 LVLTCAVTGN PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA 310 320 330 340 350 360 RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR QKGSYLTHEA 370 380 SGLDEQGEAR EAFLNGSDGH KRKEEFFI

CATM prediction

The sequence of CADM4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          330       340      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 AYAIVGGILALLVFLIICVLVGMVWCS 6.8 -41.0° 3.5 38.0 -16.8
Prolines* PYAIVGGILALLVFLIICVLVGMVWCS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 328, GLY, HA2 A, 327, GLY, O 3.43Å
A, 328, GLY, HA2 B, 327, GLY, O 3.43Å