Semaphorin-6D

UniProt data

UniProt name: SEM6D_HUMAN (Q8NFY4)

Gene name: SEMA6D; Synonyms=KIAA1479

Organism: Homo sapiens (Human).

Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

Subcellular location: Isoform 7: Cytoplasm.

Transmembrane domains:

  1. 663-683, 21 AA, Helical. {ECO:0000255}.

Sequence: 1073 AA

10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 480 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE 490 500 510 520 530 540 NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS 550 560 570 580 590 600 CGRVTPGMLA EGYEQDTEFG NTAHLGDCHE ILPTSTTPDY KIFGGPTSDM EVSSSSVTTM 610 620 630 640 650 660 ASIPEITPKV IDTWRPKLTS SRKFVVQDDP NTSDFTDPLS GIPKGVRWEV QSGESNQMVH 670 680 690 700 710 720 MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD AESAQSCTDS SGSFAKLNGL 730 740 750 760 770 780 FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP NGDTKSMVMD HRGQPPELAA LPTPESTPVL 790 800 810 820 830 840 HQKTLQAMKS HSEKAHGHGA SRKETPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS 850 860 870 880 890 900 FSNSNAHKAE KKLQNIDHPL TKSSSKRDHR RSVDSRNTLN DLLKHLNDPN SNPKAIMGDI 910 920 930 940 950 960 QMAHQNLMLD PMGSMSEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT PGVPMTSLER 970 980 990 1000 1010 1020 QRGYHKNSSQ RHSISAMPKN LNSPNGVLLS RQPSMNRGGY MPTPTGAKVD YIQGTPVSVH 1030 1040 1050 1060 1070 LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP DVPPKPSFVP QTPSVRPLNK YTY

CATM prediction

The sequence of SEM6D_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  660       670       680    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 HMNVLITCVFAAFVLGAFIAGVAVYCY 7.3 -42.8° 3.5 49.9 -22.5
Model 2 HMNVLITCVFAAFVLGAFIAGVAVYCY 7.1 -51.1° 0.1 45.0 -8.4
Model 3 HMNVLITCVFAAFVLGAFIAGVAVYCY 7.4 -53.9° 2.9 50.9 -4.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 672, PHE, HA A, 671, ALA, O 3.13Å
B, 675, GLY, HA1 A, 672, PHE, O 3.39Å
A, 672, PHE, HA B, 671, ALA, O 3.13Å
A, 675, GLY, HA1 B, 672, PHE, O 3.39Å