Delta and Notch-like epidermal growth factor-related receptor

UniProt data

UniProt name: DNER_HUMAN (Q8NFT8)

Gene name: DNER; Synonyms=BET; ORFNames=UNQ262/PRO299

Organism: Homo sapiens (Human).

Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). {ECO:0000250}.

Transmembrane domains:

  1. 641-661, 21 AA, Helical. {ECO:0000255}.

Sequence: 737 AA

10 20 30 40 50 60 MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA QPCRNGGVCT 70 80 90 100 110 120 SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS NPCHHGNCSS SSSSSSDGYL 130 140 150 160 170 180 CICNEGYEGP NCEQALPSLP ATGWTESMAP RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP 190 200 210 220 230 240 KTGQKVVEMK WDQVEVIPDI ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW 250 260 270 280 290 300 KVTATGFQQC SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL 310 320 330 340 350 360 VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY DACQRKPCQN 370 380 390 400 410 420 NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP CRNGATCISS LSGFTCQCPE 430 440 450 460 470 480 GYFGSACEEK VDPCASSPCQ NNGTCYVDGV HFTCNCSPGF TGPTCAQLID FCALSPCAHG 490 500 510 520 530 540 TCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC 550 560 570 580 590 600 ELYKDPCANV SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP 610 620 630 640 650 660 NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG 670 680 690 700 710 720 ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVSPIAYED 730 YSPDDKPLVT LIKTKDL

CATM prediction

The sequence of DNER_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    640       650       660  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 SLYIIIGALCVAFILMLIILIVGICRI 7.2 -51.0° 3.3 48.0 -14.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 644, GLY, HA1 A, 641, ILE, O 3.22Å
A, 644, GLY, HA1 B, 641, ILE, O 3.22Å