Interleukin-17 receptor E

UniProt data

UniProt name: I17RE_HUMAN (Q8NFR9)

Gene name: IL17RE; ORFNames=UNQ3056/PRO9877

Organism: Homo sapiens (Human).

Function: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. {ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:21993849}.

Subcellular location: Isoform 5: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 455-475, 21 AA, Helical. {ECO:0000255}.

Sequence: 667 AA

10 20 30 40 50 60 MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW 70 80 90 100 110 120 WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP 130 140 150 160 170 180 AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS 190 200 210 220 230 240 FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP 250 260 270 280 290 300 CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE 310 320 330 340 350 360 AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL 370 380 390 400 410 420 TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL 430 440 450 460 470 480 IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV SYRHLGLLIL ALLALLTLLG VVLALTCRRP 490 500 510 520 530 540 QSGPGPARPV LLLHAADSEA QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW 550 560 570 580 590 600 LWAARTRVAR EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK 610 620 630 640 650 660 GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL ELCSRLEREA ARLADLG

CATM prediction

The sequence of I17RE_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          460       470      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 YRHLGLLILALLALLTLLGVVLALTCR 7.2 -54.7° 0.9 50.2 -1.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 470, GLY, HA1 A, 467, THR, O 3.32Å
B, 471, VAL, HA A, 470, GLY, O 3.36Å
A, 470, GLY, HA1 B, 467, THR, O 3.32Å
A, 471, VAL, HA B, 470, GLY, O 3.36Å