Polypeptide N-acetylgalactosaminyltransferase 11

UniProt data

UniProt name: GLT11_HUMAN (Q8NCW6)

Gene name: GALNT11

Organism: Homo sapiens (Human).

Function: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N- acetylgalactosaminyltransferases catalyze the transfer of an N- acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:24226769}.

Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:11925450}; Single-pass type II membrane protein {ECO:0000269|PubMed:11925450}.

Transmembrane domains:

  1. 7-29, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 608 AA

10 20 30 40 50 60 MGSVTVRYFC YGCLFTSATW TVLLFVYFNF SEVTQPLKNV PVKGSGPHGP SPKKFYPRFT 70 80 90 100 110 120 RGPSRVLEPQ FKANKIDDVI DSRVEDPEEG HLKFSSELGM IFNERDQELR DLGYQKHAFN 130 140 150 160 170 180 MLISDRLGYH RDVPDTRNAA CKEKFYPPDL PAASVVICFY NEAFSALLRT VHSVIDRTPA 190 200 210 220 230 240 HLLHEIILVD DDSDFDDLKG ELDEYVQKYL PGKIKVIRNT KREGLIRGRM IGAAHATGEV 250 260 270 280 290 300 LVFLDSHCEV NVMWLQPLLA AIREDRHTVV CPVIDIISAD TLAYSSSPVV RGGFNWGLHF 310 320 330 340 350 360 KWDLVPLSEL GRAEGATAPI KSPTMAGGLF AMNRQYFHEL GQYDSGMDIW GGENLEISFR 370 380 390 400 410 420 IWMCGGKLFI IPCSRVGHIF RKRRPYGSPE GQDTMTHNSL RLAHVWLDEY KEQYFSLRPD 430 440 450 460 470 480 LKTKSYGNIS ERVELRKKLG CKSFKWYLDN VYPEMQISGS HAKPQQPIFV NRGPKRPKVL 490 500 510 520 530 540 QRGRLYHLQT NKCLVAQGRP SQKGGLVVLK ACDYSDPNQI WIYNEEHELV LNSLLCLDMS 550 560 570 580 590 600 ETRSSDPPRL MKCHGSGGSQ QWTFGKNNRL YQVSVGQCLR AVDPLGQKGS VAMAICDGSS SQQWHLEG

CATM prediction

The sequence of GLT11_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20        30 
 +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 VTVRYFCYGCLFTSATWTVLLFVYFNFSE 7.3 -43.0° 2.4 43.9 -30.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 9, PHE, HA A, 8, TYR, O 3.35Å
B, 12, GLY, HA1 A, 9, PHE, O 3.28Å
B, 13, CYS, HA A, 16, THR, OG1 2.40Å
A, 9, PHE, HA B, 8, TYR, O 3.35Å
A, 12, GLY, HA1 B, 9, PHE, O 3.28Å
A, 13, CYS, HA B, 16, THR, OG1 2.40Å