Neuropilin and tolloid-like protein 2

UniProt data

UniProt name: NETO2_HUMAN (Q8NC67)

Gene name: NETO2; Synonyms=BTCL2; ORFNames=UNQ1926/PRO4401

Organism: Homo sapiens (Human).

Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 348-368, 21 AA, Helical. {ECO:0000255}.

Sequence: 525 AA

10 20 30 40 50 60 MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP 70 80 90 100 110 120 NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR 130 140 150 160 170 180 YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE 190 200 210 220 230 240 LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA 250 260 270 280 290 300 VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS 310 320 330 340 350 360 TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV 370 380 390 400 410 420 LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD 430 440 450 460 470 480 NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK 490 500 510 520 SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF

CATM prediction

The sequence of NETO2_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       350       360       37
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 KTHGTIIGITSGIVLVLLIISILVQVK 6.8 -27.9° 6.0 47.3 -34.7
Model 2 KTHGTIIGITSGIVLVLLIISILVQVK 6.9 -43.0° 2.4 44.1 -30.3
Model 3 KTHGTIIGITSGIVLVLLIISILVQVK 6.3 -37.9° 6.0 58.8 -21.2
Model 4 KTHGTIIGITSGIVLVLLIISILVQVK 6.7 -54.9° 4.9 52.9 -7.4
Model 5 KTHGTIIGITSGIVLVLLIISILVQVK 7.4 -53.7° 2.9 50.7 -7.3
Model 6 KTHGTIIGITSGIVLVLLIISILVQVK 7.1 -55.2° 5.8 47.2 -6.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 349, THR, HA A, 348, GLY, O 2.57Å
B, 352, GLY, HA1 A, 349, THR, O 3.36Å
A, 349, THR, HA B, 348, GLY, O 2.57Å
A, 352, GLY, HA1 B, 349, THR, O 3.36Å