UDP-glucuronic acid decarboxylase 1

UniProt data

UniProt name: UXS1_HUMAN (Q8NBZ7)

Gene name: UXS1; ORFNames=UNQ2538/PRO6079

Organism: Homo sapiens (Human).

Function: Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.

Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 20-40, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 420 AA

10 20 30 40 50 60 MVSKALLRLV SAVNRRRMKL LLGIALLAYV ASVWGNFVNM RSIQENGELK IESKIEEMVE 70 80 90 100 110 120 PLREKIRDLE KSFTQKYPPV KFLSEKDRKR ILITGGAGFV GSHLTDKLMM DGHEVTVVDN 130 140 150 160 170 180 FFTGRKRNVE HWIGHENFEL INHDVVEPLY IEVDQIYHLA SPASPPNYMY NPIKTLKTNT 190 200 210 220 230 240 IGTLNMLGLA KRVGARLLLA STSEVYGDPE VHPQSEDYWG HVNPIGPRAC YDEGKRVAET 250 260 270 280 290 300 MCYAYMKQEG VEVRVARIFN TFGPRMHMND GRVVSNFILQ ALQGEPLTVY GSGSQTRAFQ 310 320 330 340 350 360 YVSDLVNGLV ALMNSNVSSP VNLGNPEEHT ILEFAQLIKN LVGSGSEIQF LSEAQDDPQK 370 380 390 400 410 RKPDIKKAKL MLGWEPVVPL EEGLNKAIHY FRKELEYQAN NQYIPKPKPA RIKKGRTRHS

CATM prediction

The sequence of UXS1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     20        30        40  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 RMKLLLGIALLAYVASVWGNFVNMRSI 7.3 -42.8° 4.5 35.2 -14.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 32, SER, HA A, 31, ALA, O 3.21Å
B, 35, GLY, HA1 A, 32, SER, O 3.28Å
B, 39, ASN, HD21 A, 36, ASN, OD1 2.32Å
A, 32, SER, HA B, 31, ALA, O 3.21Å
A, 35, GLY, HA1 B, 32, SER, O 3.28Å
A, 39, ASN, HD21 B, 36, ASN, OD1 2.32Å