Synaptotagmin-8

UniProt data

UniProt name: SYT8_HUMAN (Q8NBV8)

Gene name: SYT8

Organism: Homo sapiens (Human).

Function: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.

Transmembrane domains:

  1. 49-69, 21 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 401 AA

10 20 30 40 50 60 MLHLHGWQTM QGRKMGHPPV SPSAPAPAGT TAIPGLIPDL VAGTPWPRWA LIAGALAAGV 70 80 90 100 110 120 LLVSCLLCAA CCCCRRHRKK PRDKESVGLG SARGTTTTHL VQPDVDGLES SPGDAQQWGC 130 140 150 160 170 180 LQLSLEFDFG SQEIRVGLRQ AADLRPGGTV DPYARVSVST QAGHRHETKV HRGTLCPVFD 190 200 210 220 230 240 ETCCFHIPQA ELPGATLQVQ LFNFKRFSGH EPLGELRLPL GTVDLQHVLE HWYLLGPPAA 250 260 270 280 290 300 TQPEQVGELC FSLRYVPSSG RLTVVVLEAR GLRPGLAEPY VKVQLMLNQR KWKKRKTATK 310 320 330 340 350 360 KGTAAPYFNE AFTFLVPFSQ VQNVDLVLAV WDRSLPLRTE PVGKVHLGAR ASGQPLQHWA 370 380 390 400 DMLAHARRPI AQRHPLRPAR EVDRMLALQP RLRLRLPLPH S

CATM prediction

The sequence of SYT8_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      50        60        70 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 WARWALIAGALAAGVLLVSCLLCAACC 7.1 -38.0° 5.7 34.2 -21.7
Model 2 WARWALIAGALAAGVLLVSCLLCAACC 7.4 -22.0° 3.1 40.0 -7.1
Model 3 WARWALIAGALAAGVLLVSCLLCAACC 7.2 -54.7° 0.3 45.0 -1.3
Prolines* WPRWALIAGALAAGVLLVSCLLCAACC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 51, LEU, HA A, 50, ALA, O 2.98Å
B, 54, GLY, HA1 A, 51, LEU, O 3.32Å
A, 51, LEU, HA B, 50, ALA, O 2.98Å
A, 54, GLY, HA1 B, 51, LEU, O 3.32Å