Late secretory pathway protein AVL9 homolog

UniProt data

UniProt name: AVL9_HUMAN (Q8NBF6)

Gene name: AVL9; Synonyms=KIAA0241

Organism: Homo sapiens (Human).

Function: Functions in cell migration. {ECO:0000269|PubMed:22595670}.

Subcellular location: Recycling endosome {ECO:0000269|PubMed:22595670}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 214-230, 17 AA, Helical. {ECO:0000255}.

Sequence: 648 AA

10 20 30 40 50 60 MEKARRGGDG VPRGPVLHIV VVGFHHKKGC QVEFSYPPLI PGDGHDSHTL PEEWKYLPFL 70 80 90 100 110 120 ALPDGAHNYQ EDTVFFHLPP RNGNGATVFG ISCYRQIEAK ALKVRQADIT RETVQKSVCV 130 140 150 160 170 180 LSKLPLYGLL QAKLQLITHA YFEEKDFSQI SILKELYEHM NSSLGGASLE GSQVYLGLSP 190 200 210 220 230 240 RDLVLHFRHK VLILFKLILL EKKVLFYISP VNKLVGALMT VLSLFPGMIE HGLSDCSQYR 250 260 270 280 290 300 PRKSMSEDGG LQESNPCADD FVSASTADVS HTNLGTIRKV MAGNHGEDAA MKTEEPLFQV 310 320 330 340 350 360 EDSSKGQEPN DTNQYLKPPS RPSPDSSESD WETLDPSVLE DPNLKEREQL GSDQTNLFPK 370 380 390 400 410 420 DSVPSESLPI TVQPQANTGQ VVLIPGLISG LEEDQYGMPL AIFTKGYLCL PYMALQQHHL 430 440 450 460 470 480 LSDVTVRGFV AGATNILFRQ QKHLSDAIVE VEEALIQIHD PELRKLLNPT TADLRFADYL 490 500 510 520 530 540 VRHVTENRDD VFLDGTGWEG GDEWIRAQFA VYIHALLAAT LQLDNEKILS DYGTTFVTAW 550 560 570 580 590 600 KNTHNYRVWN SNKHPALAEI NPNHPFQGQY SVSDMKLRFS HSVQNSERGK KIGNVMVTTS 610 620 630 640 RNVVQTGKAV GQSVGGAFSS AKTAMSSWLS TFTTSTSQSL TEPPDEKP

CATM prediction

The sequence of AVL9_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           220       230 
    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 VNKLVGALMTVLSLFAGMIEHGL 7.2 -40.7° 3.5 37.9 -25.4
Model 2 VNKLVGALMTVLSLFAGMIEHGL 6.9 -55.0° 0.9 49.9 -12.3
Model 3 VNKLVGALMTVLSLFAGMIEHGL 7.1 -50.0° 2.9 47.0 -3.1
Prolines* VNKLVGALMTVLSLFPGMIEHGL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 220, THR, HA A, 223, SER, OG 3.19Å
B, 224, LEU, HA A, 223, SER, O 3.21Å
B, 227, GLY, HA1 A, 224, LEU, O 3.24Å
A, 220, THR, HA B, 223, SER, OG 3.19Å
A, 224, LEU, HA B, 223, SER, O 3.21Å
A, 227, GLY, HA1 B, 224, LEU, O 3.24Å