Synaptotagmin-14

UniProt data

UniProt name: SYT14_HUMAN (Q8NB59)

Gene name: SYT14

Organism: Homo sapiens (Human).

Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Subcellular location: Membrane {ECO:0000269|PubMed:21835308}; Single-pass type III membrane protein {ECO:0000269|PubMed:21835308}. Note=Localized in perinuclear and submembranous regions.

Transmembrane domains:

  1. 25-47, 23 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 555 AA

10 20 30 40 50 60 MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD 70 80 90 100 110 120 LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN 130 140 150 160 170 180 YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT 190 200 210 220 230 240 PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM 250 260 270 280 290 300 SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV 310 320 330 340 350 360 HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG 370 380 390 400 410 420 EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL 430 440 450 460 470 480 IGLLYNATTG RLSAEVIKGS HFKNLAANRP PNTYVKLTLL NSMGQEMSKC KTSIRRGQPN 490 500 510 520 530 540 PVYKETFVFQ VALFQLSDVT LILSVYNKRS MKRKEMIGWI SLGLNSSGEE ELNHWTEMKE 550 SKGQQVCRWH ALLES

CATM prediction

The sequence of SYT14_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          30        40        5
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 SAEAVGFLSAVGVFIILMLLLFLYINKKF 6.9 -40.0° 4.0 38.0 -18.8
Prolines* SPEAVGFLSAVGVFIILMLLLFLYINKKF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session