Transmembrane protein 102

UniProt data

UniProt name: TM102_HUMAN (Q8N9M5)

Gene name: TMEM102

Organism: Homo sapiens (Human).

Function: Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:17828305}; Single-pass membrane protein {ECO:0000269|PubMed:17828305}. Note=Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.

Transmembrane domains:

  1. 261-278, 18 AA, Helical. {ECO:0000255}.

Sequence: 508 AA

10 20 30 40 50 60 MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW SDGPKPGADL 70 80 90 100 110 120 LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD LGHAPLGPYA RGPHYDAGFT 130 140 150 160 170 180 LLVPMFSLDG TELQLDLESC YAQVCLPEMV CGTPIREMWQ DCLGPPVPGA RDSIHRTESE 190 200 210 220 230 240 ESSKDWQSSV DQPHSYVTEH EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT 250 260 270 280 290 300 KAAVESPVPK PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT 310 320 330 340 350 360 TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV PGGGTERPCA 370 380 390 400 410 420 SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT RAAAPYLLRT LLYWACERLP 430 440 450 460 470 480 ALYLARPENA GACCLGLLDE LGRVLEAGTL PHYFLNGRQL RTGDDSAALL GELARLRGDP 490 500 ARALRAAVEE AKVARKGGGL AGVGGGAH

CATM prediction

The sequence of TM102_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    260       270       28
  |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 WATLCSAQVAAWFFATLAAVAESL 7.2 -37.0° 2.3 35.9 -2.9
Prolines* WPTLCSAQVAAWFFATLAAVAESL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 272, ALA, HA A, 271, PHE, O 3.45Å
B, 276, ALA, HA A, 275, ALA, O 3.39Å
A, 272, ALA, HA B, 271, PHE, O 3.45Å
A, 276, ALA, HA B, 275, ALA, O 3.39Å