Discoidin, CUB and LCCL domain-containing protein 1

UniProt data

UniProt name: DCBD1_HUMAN (Q8N8Z6)

Gene name: DCBLD1

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 460-480, 21 AA, Helical. {ECO:0000255}.

Sequence: 715 AA

10 20 30 40 50 60 MVPGARGGGA LARAAGRGLL ALLLAVSAPL RLQAEELGDG CGHLVTYQDS GTMTSKNYPG 70 80 90 100 110 120 TYPNHTVCEK TITVPKGKRL ILRLGDLDIE SQTCASDYLL FTSSSDQYGP YCGSMTVPKE 130 140 150 160 170 180 LLLNTSEVTV RFESGSHISG RGFLLTYASS DHPDLITCLE RASHYLKTEY SKFCPAGCRD 190 200 210 220 230 240 VAGDISGNMV DGYRDTSLLC KAAIHAGIIA DELGGQISVL QRKGISRYEG ILANGVLSRD 250 260 270 280 290 300 GSLSDKRFLF TSNGCSRSLS FEPDGQIRAS SSWQSVNESG DQVHWSPGQA RLQDQGPSWA 310 320 330 340 350 360 SGDSSNNHKP REWLEIDLGE KKKITGIRTT GSTQSNFNFY VKSFVMNFKN NNSKWKTYKG 370 380 390 400 410 420 IVNNEEKVFQ GNSNFRDPVQ NNFIPPIVAR YVRVVPQTWH QRIALKVELI GCQITQGNDS 430 440 450 460 470 480 LVWRKTSQST SVSTKKEDET ITRPIPSEET STGINITTVA IPLVLLVVLV FAGMGIFAAF 490 500 510 520 530 540 RKKKKKGSPY GSAEAQKTDC WKQIKYPFAR HQSAEFTISY DNEKEMTQKL DLITSDMADY 550 560 570 580 590 600 QQPLMIGTGT VTRKGSTFRP MDTDAEEAGV STDAGGHYDC PQRAGRHEYA LPLAPPEPEY 610 620 630 640 650 660 ATPIVERHVL RAHTFSAQSG YRVPGPQPGH KHSLSSGGFS PVAGVGAQDG DYQRPHSAQP 670 680 690 700 710 ADRGYDRPKA VSALATESGH PDSQKPPTHP GTSDSYSAPR DCLTPLNQTA MTALL

CATM prediction

The sequence of DCBD1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     460       470       480 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 TTVAIALVLLVVLVFAGMGIFAAFRKK 7.3 -47.0° 1.3 45.1 -10.6
Model 2 TTVAIALVLLVVLVFAGMGIFAAFRKK 7.0 -55.0° 1.5 44.8 -7.8
Prolines* TTVAIPLVLLVVLVFAGMGIFAAFRKK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 475, GLY, HA1 A, 472, ALA, O 3.25Å
B, 476, ILE, HA A, 475, GLY, O 3.46Å
A, 475, GLY, HA1 B, 472, ALA, O 3.25Å
A, 476, ILE, HA B, 475, GLY, O 3.46Å