SIGLEC family-like protein 1

UniProt data

UniProt name: SIGL1_HUMAN (Q8N7X8)

Gene name: SIGLECL1; Synonyms=C19orf75

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 118-138, 21 AA, Helical. {ECO:0000255}.

Sequence: 197 AA

10 20 30 40 50 60 MLPLLQLVPA KLLNSSCSLE KTLQCSCSFH GIPTPSVQWW MGGVPVGVDG MDGSLQVTST 70 80 90 100 110 120 MLGPWANSTI SLTEEPEMGM RLLCEGKNQN GTHALSILLM SRKSSLAAQA FVKGLIQGAI 130 140 150 160 170 180 YAGIVIALLF LCLLPLIVKH IRKKQAKKAA AIRAKKSSKV RASQELEMSL KPEEPGKPVV 190 ATFSESRILE KQDKRAS

CATM prediction

The sequence of SIGL1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       120       130       14
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 LIQGAIYAGIVIALLFLCLLALIVKHI 6.9 -49.9° 2.8 47.1 -28.4
Model 2 LIQGAIYAGIVIALLFLCLLALIVKHI 7.2 -51.0° 6.0 45.0 -4.9
Prolines* LIQGAIYAGIVIALLFLCLLPLIVKHI          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 120, ILE, HA A, 119, ALA, O 2.97Å
B, 123, GLY, HA1 A, 120, ILE, O 2.89Å
A, 120, ILE, HA B, 119, ALA, O 2.97Å
A, 123, GLY, HA1 B, 120, ILE, O 2.89Å