Leucine-rich repeat-containing protein 52

UniProt data

UniProt name: LRC52_HUMAN (Q8N7C0)

Gene name: LRRC52

Organism: Homo sapiens (Human).

Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties. {ECO:0000269|PubMed:22547800, ECO:0000269|PubMed:23129643}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Expression at the cell surface may require the presence of KCNU1.

Transmembrane domains:

  1. 245-265, 21 AA, Helical. {ECO:0000255}.

Sequence: 313 AA

10 20 30 40 50 60 MSLASGPGPG WLLFSFGMGL VSGSKCPNNC LCQAQEVICT GKQLTEYPLD IPLNTRRLFL 70 80 90 100 110 120 NENRITSLPA MHLGLLSDLV YLDCQNNRIR EVMDYTFIGV FKLIYLDLSS NNLTSISPFT 130 140 150 160 170 180 FSVLSNLVQL NIANNPHLLS LHKFTFANTT SLRYLDLRNT GLQTLDSAAL YHLTTLETLF 190 200 210 220 230 240 LSGNPWKCNC SFLDFAIFLI VFHMDPSDDL NATCVEPTEL TGWPITRVGN PLRYMCITHL 250 260 270 280 290 300 DHKDYIFLLL IGFCIFAAGT VAAWLTGVCA VLYQNTRHKS SEEDEDEAGT RVEVSRRIFQ 310 TQTSSVQEFP QLI

CATM prediction

The sequence of LRC52_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          250       260      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 HKDYIFLLLIGFCIFAAGTVAAWLTGV 7.2 -43.8° 1.8 45.0 -34.7
Model 2 HKDYIFLLLIGFCIFAAGTVAAWLTGV 7.1 -40.2° 2.7 34.2 -7.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 256, PHE, HA A, 255, ILE, O 3.36Å
B, 259, GLY, HA1 A, 256, PHE, O 3.15Å
B, 260, THR, HA A, 259, GLY, O 3.41Å
A, 256, PHE, HA B, 255, ILE, O 3.36Å
A, 259, GLY, HA1 B, 256, PHE, O 3.15Å
A, 260, THR, HA B, 259, GLY, O 3.41Å