Protocadherin-20

UniProt data

UniProt name: PCD20_HUMAN (Q8N6Y1)

Gene name: PCDH20; Synonyms=PCDH13

Organism: Homo sapiens (Human).

Function: Potential calcium-dependent cell-adhesion protein.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 891-911, 21 AA, Helical. {ECO:0000255}.

Sequence: 951 AA

10 20 30 40 50 60 MRGRGNARSS QALGVSWCPA TWHPRLDMGR LHRPRSSTSY RNLPHLFLFF LFVGPFSCLG 70 80 90 100 110 120 SYSRATELLY SLNEGLPAGV LIGSLAEDLR LLPRSAGRPD PQSQLPERTG AEWNPPLSFS 130 140 150 160 170 180 LASRGLSGQY VTLDNRSGEL HTSAQEIDRE ALCVEGGGGT AWSGSVSISS SPSDSCLLLL 190 200 210 220 230 240 DVLVLPQEYF RFVKVKIAIR DINDNAPQFP VSQISVWVPE NAPVNTRLAI EHPAVDPDVG 250 260 270 280 290 300 INGVQTYRLL DYHGMFTLDV EENENGERTP YLIVMGALDR ETQDQYVSII IAEDGGSPPL 310 320 330 340 350 360 LGSATLTIGI SDINDNCPLF TDSQINVTVY GNATVGTPIA AVQAVDKDLG TNAQITYSYS 370 380 390 400 410 420 QKVPQASKDL FHLDENTGVI KLFSKIGGSV LESHKLTILA NGPGCIPAVI TALVSIIKVI 430 440 450 460 470 480 FRPPEIVPRY IANEIDGVVY LKELEPVNTP IAFFTIRDPE GKYKVNCYLD GEGPFRLSPY 490 500 510 520 530 540 KPYNNEYLLE TTKPMDYELQ QFYEVAVVAW NSEGFHVKRV IKVQLLDDND NAPIFLQPLI 550 560 570 580 590 600 ELTIEENNSP NAFLTKLYAT DADSEERGQV SYFLGPDAPS YFSLDSVTGI LTVSTQLDRE 610 620 630 640 650 660 EKEKYRYTVR AVDCGKPPRE SVATVALTVL DKNDNSPRFI NKDFSFFVPE NFPGYGEIGV 670 680 690 700 710 720 ISVTDADAGR NGWVALSVVN QSDIFVIDTG KGMLRAKVSL DREQQSSYTL WVEAVDGGEP 730 740 750 760 770 780 ALSSTAKITI LLLDINDNPP LVLFPQSNMS YLLVLPSTLP GSPVTEVYAV DKDTGMNAVI 790 800 810 820 830 840 AYSIIGRRGP RPESFRIDPK TGNITLEEAL LQTDYGLHRL LVKVSDHGYP EPLHSTVMVN 850 860 870 880 890 900 LFVNDTVSNE SYIESLLRKE PEINIEEKEP QISIEPTHRK VESVSCMPTL VALSVISLGS 910 920 930 940 950 ITLVTGMGIY ICLRKGEKHP REDENLEVQI PLKGKIDLHM RERKPMDISN I

CATM prediction

The sequence of PCD20_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    890       900       910  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ATLVALSVISLGSITLVTGMGIYICLR 7.2 -55.0° 2.4 48.0 -12.5
Model 2 ATLVALSVISLGSITLVTGMGIYICLR 7.3 -50.9° 2.5 44.7 -11.7
Prolines* PTLVALSVISLGSITLVTGMGIYICLR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 903, LEU, HA A, 902, THR, O 3.35Å
B, 906, GLY, HA1 A, 903, LEU, O 3.10Å
A, 903, LEU, HA B, 902, THR, O 3.35Å
A, 906, GLY, HA1 B, 903, LEU, O 3.10Å