Interleukin-22 receptor subunit alpha-1

UniProt data

UniProt name: I22R1_HUMAN (Q8N6P7)

Gene name: IL22RA1; Synonyms=IL22R

Organism: Homo sapiens (Human).

Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 229-249, 21 AA, Helical. {ECO:0000255}.

Sequence: 574 AA

10 20 30 40 50 60 MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD TVYSIEYKTY 70 80 90 100 110 120 GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS AGGRSATKMT DRFSSLQHTT 130 140 150 160 170 180 LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG 190 200 210 220 230 240 GKQREYEFFG LTPDTEFLGT IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG 250 260 270 280 290 300 FLVAVLCYLS YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ 310 320 330 340 350 360 YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS YAPNAAPEVG 370 380 390 400 410 420 PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP PSYGVCMEGS GKDSPTGTLS 430 440 450 460 470 480 SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV TSLAMEESQE AKSLHQPLGI CTDRTSDPNV 490 500 510 520 530 540 LHSGEEGTPQ YLKGQLPLLS SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK 550 560 570 DEAKSPAPET SDLEQPTELD SLFRGLALTV QWES

CATM prediction

The sequence of I22R1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      230       240       250
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 TWTYSFSGAFLFSMGFLVAVLCYLSYR 7.3 -47.0° 2.2 45.2 -33.6
Model 2 TWTYSFSGAFLFSMGFLVAVLCYLSYR 7.1 -54.2° 3.6 35.5 -24.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 229, TYR, HH A, 229, TYR, OH 2.20Å
B, 237, PHE, HA A, 236, LEU, O 3.43Å
B, 240, GLY, HA1 A, 237, PHE, O 3.21Å
A, 237, PHE, HA B, 236, LEU, O 3.43Å
A, 240, GLY, HA1 B, 237, PHE, O 3.21Å