Small integral membrane protein 20

UniProt data

UniProt name: SMI20_HUMAN (Q8N5G0)

Gene name: SMIM20; Synonyms=C4orf52, MITRAC7 {ECO:0000303|PubMed:26321642}

Organism: Homo sapiens (Human).

Function: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Promotes the progression of complex assembly after the association of MT- CO1/COX1 with COX4I1 and COX6C. Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover. {ECO:0000269|PubMed:26321642}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:26321642}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 7-27, 21 AA, Helical. {ECO:0000255}.

Sequence: 67 AA

10 20 30 40 50 60 MSRNLRTALI FGGFISLIGA AFYPIYFRPL MRLEEYKKEQ AINRAGIVQE DVQPPGLKVW SDPFGRK

CATM prediction

The sequence of SMI20_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       110       120       13
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 NLRTALIFGGFISLIGAAFYAIYFRAL 7.0 -53.0° 1.9 45.2 -25.4
Model 2 NLRTALIFGGFISLIGAAFYAIYFRAL 6.8 -43.0° 2.4 44.0 -24.9
Prolines* NLRTALIFGGFISLIGAAFYPIYFRPL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 117, SER, HA A, 116, ILE, O 3.23Å
B, 120, GLY, HA1 A, 117, SER, O 2.86Å
A, 117, SER, HA B, 116, ILE, O 3.23Å
A, 120, GLY, HA1 B, 117, SER, O 2.86Å