Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

UniProt data

UniProt name: GBGT1_HUMAN (Q8N5D6)

Gene name: GBGT1; ORFNames=UNQ2513/PRO6002

Organism: Homo sapiens (Human).

Function: Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens.

Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 6-26, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 347 AA

10 20 30 40 50 60 MHRRRLALGL GFCLLAGTSL SVLWVYLENW LPVSYVPYYL PCPEIFNMKL HYKREKPLQP 70 80 90 100 110 120 VVWSQYPQPK LLEHRPTQLL TLTPWLAPIV SEGTFNPELL QHIYQPLNLT IGVTVFAVGK 130 140 150 160 170 180 YTHFIQSFLE SAEEFFMRGY RVHYYIFTDN PAAVPGVPLG PHRLLSSIPI QGHSHWEETS 190 200 210 220 230 240 MRRMETISQH IAKRAHREVD YLFCLDVDMV FRNPWGPETL GDLVAAIHPS YYAVPRQQFP 250 260 270 280 290 300 YERRRVSTAF VADSEGDFYY GGAVFGGQVA RVYEFTRGCH MAILADKANG IMAAWREESH 310 320 330 340 LNRHFISNKP SKVLSPEYLW DDRKPQPPSL KLIRFSTLDK DISCLRS

CATM prediction

The sequence of GBGT1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         10        20        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 RRRLALGLGFCLLAGTSLSVLWVYLEN 7.2 -43.9° 1.8 45.0 -28.2
Model 2 RRRLALGLGFCLLAGTSLSVLWVYLEN 7.1 -43.0° 2.4 44.0 -20.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 14, LEU, HA A, 13, CYS, O 3.37Å
B, 17, GLY, HA1 A, 14, LEU, O 3.16Å
B, 18, THR, HA A, 17, GLY, O 3.45Å
B, 21, SER, HG1 A, 18, THR, O 2.51Å
A, 14, LEU, HA B, 13, CYS, O 3.37Å
A, 17, GLY, HA1 B, 14, LEU, O 3.16Å
A, 18, THR, HA B, 17, GLY, O 3.45Å
A, 21, SER, HG1 B, 18, THR, O 2.51Å