Fibroblast growth factor receptor-like 1

UniProt data

UniProt name: FGRL1_HUMAN (Q8N441)

Gene name: FGFRL1; Synonyms=FGFR5, FHFR; ORFNames=UNQ480/PRO943

Organism: Homo sapiens (Human).

Function: Has a negative effect on cell proliferation. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000269|PubMed:12813049}; Single-pass type I membrane protein {ECO:0000269|PubMed:12813049}. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.

Transmembrane domains:

  1. 379-399, 21 AA, Helical. {ECO:0000255}.

Sequence: 504 AA

10 20 30 40 50 60 MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL 70 80 90 100 110 120 TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI 130 140 150 160 170 180 SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP 190 200 210 220 230 240 DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ 250 260 270 280 290 300 RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG 310 320 330 340 350 360 QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK 370 380 390 400 410 420 PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP 430 440 450 460 470 480 GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT 490 500 HTHTHSHTHS HVEGKVHQHI HYQC

CATM prediction

The sequence of FGRL1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      380       390       400
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 AWAVVIGIAAGAVFILGTLLLWLCQAQ 7.0 -52.2° 0.6 47.7 -14.2
Prolines* PWPVVIGIPAGAVFILGTLLLWLCQAQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 382, GLY, HA1 A, 379, VAL, O 3.15Å
B, 383, ILE, HA A, 382, GLY, O 2.96Å
A, 382, GLY, HA1 B, 379, VAL, O 3.15Å
A, 383, ILE, HA B, 382, GLY, O 2.96Å