Leukocyte immunoglobulin-like receptor subfamily B member 2

UniProt data

UniProt name: LIRB2_HUMAN (Q8N423)

Gene name: LILRB2; Synonyms=ILT4, LIR2, MIR10

Organism: Homo sapiens (Human).

Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 462-482, 21 AA, Helical. {ECO:0000255}.

Sequence: 598 AA

10 20 30 40 50 60 MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ GSLEAQEYRL 70 80 90 100 110 120 YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY YSRARWSELS DPLVLVMTGA 130 140 150 160 170 180 YPKPTLSAQP SPVVTSGGRV TLQCESQVAF GGFILCKEGE EEHPQCLNSQ PHARGSSRAI 190 200 210 220 230 240 FSVGPVSPNR RWSHRCYGYD LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES 250 260 270 280 290 300 LTLQCVSDVG YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH 310 320 330 340 350 360 NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ FHTFLLTKAG 370 380 390 400 410 420 AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL NSDPYLLSHP SEPLELVVSG 430 440 450 460 470 480 PSMGSSPPPT GPISTPAGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVV LLLLLLLLLF 490 500 510 520 530 540 LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ 550 560 570 580 590 PEDGVEMDTR AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH

CATM prediction

The sequence of LIRB2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   460       470       480   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 LGVVIGILVAVVLLLLLLLLLFLILRH 6.5 -47.0° 3.3 54.0 -16.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session