Cell adhesion molecule 2

UniProt data

UniProt name: CADM2_HUMAN (Q8N3J6)

Gene name: CADM2; Synonyms=IGSF4D, NECL3

Organism: Homo sapiens (Human).

Function: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. {ECO:0000269|PubMed:17967169}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:17967169}; Single-pass type I membrane protein {ECO:0000269|PubMed:17967169}. Cell junction, synapse {ECO:0000269|PubMed:17967169}. Cell projection, axon {ECO:0000269|PubMed:17967169}. Note=Found in the axoplasm of myelinated axons.

Transmembrane domains:

  1. 368-388, 21 AA, Helical. {ECO:0000255}.

Sequence: 435 AA

10 20 30 40 50 60 MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND NTSLQWSNPA 70 80 90 100 110 120 QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG QYTCSLFTMP VKTSKAYLTV 130 140 150 160 170 180 LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG SKPAADIRWF KNDKEIKDVK YLKEEDANRK 190 200 210 220 230 240 TFTVSSTLDF RVDRSDDGVA VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE 250 260 270 280 290 300 GQPLILTCES KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN 310 320 330 340 350 360 TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT SSIRDPNALA 370 380 390 400 410 420 GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL TNEAKGAEDA PDADTAIINA 430 EGSQVNAEEK KEYFI

CATM prediction

The sequence of CADM2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       370       380       39
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 ADHALIGGIVAVVVFVTLCSIFLLGRY 6.7 -40.2° 4.1 37.9 -26.6
Model 2 ADHALIGGIVAVVVFVTLCSIFLLGRY 6.5 -54.3° 3.6 35.1 -9.1
Prolines* PDHALIGGIVAVVVFVTLCSIFLLGRY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 371, GLY, HA1 A, 368, ALA, O 2.77Å
B, 372, GLY, HA2 A, 371, GLY, O 3.41Å
A, 371, GLY, HA1 B, 368, ALA, O 2.77Å
A, 372, GLY, HA2 B, 371, GLY, O 3.41Å