UniProt data
UniProt name: MUC15_HUMAN (Q8N387)
Gene name: MUC15; ORFNames=UNQ750/PRO1481
Organism: Homo sapiens (Human).
Function: May play a role in the cell adhesion to the extracellular matrix.
Subcellular location: Isoform 2: Secreted {ECO:0000305}.
Transmembrane domains:
- 237-257, 21 AA, Helical. {ECO:0000255}.
Sequence: 334 AA
10 20 30 40 50 60
MLALAKILLI STLFYSLLSG SHGKENQDIN TTQNIAEVFK TMENKPISLE SEANLNSDKE
70 80 90 100 110 120
NITTSNLKAS HSPPLNLPNN SHGITDFSSN SSAEHSLGSL KPTSTISTSP PLIHSFVSKV
130 140 150 160 170 180
PWNAPIADED LLPISAHPNA TPALSSENFT WSLVNDTVKT PDNSSITVSI LSSEPTSPSV
190 200 210 220 230 240
TPLIVEPSGW LTTNSDSFTG FTPYQEKTTL QPTLKFTNNS KLFPNTSDPQ KENRNTGIVF
250 260 270 280 290 300
GAILGAILGV SLLTLVGYLL CGKRKTDSFS HRRLYDDRNE PVLRLDNAPE PYDVSFGNSS
310 320 330
YYNPTLNDSA MPESEENARD GIPMDDIPPL RTSV
CATM prediction
The sequence of MUC15_HUMAN returned 6 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 240 250 2 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RNTGIVFGAILGAILGVSLLTLVGYLL | 6.3 | -34.0° | 0.2 | 56.9 | -43.8 |
| Model 2 | RNTGIVFGAILGAILGVSLLTLVGYLL | 6.4 | -47.7° | 0.7 | 54.1 | -32.5 |
| Model 3 | RNTGIVFGAILGAILGVSLLTLVGYLL | 6.4 | -49.7° | 2.8 | 47.0 | -28.0 |
| Model 4 | RNTGIVFGAILGAILGVSLLTLVGYLL | 6.4 | -42.8° | 2.2 | 62.1 | -27.8 |
| Model 5 | RNTGIVFGAILGAILGVSLLTLVGYLL | 6.6 | -54.9° | 5.0 | 52.9 | -11.9 |
| Model 6 | RNTGIVFGAILGAILGVSLLTLVGYLL | 7.1 | -54.0° | 4.8 | 41.0 | -7.9 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 238, ILE, HA | A, 237, GLY, O | 2.62Å |
| B, 241, GLY, HA1 | A, 238, ILE, O | 2.59Å |
| B, 242, ALA, HA | A, 241, GLY, O | 2.41Å |
| B, 245, GLY, HA1 | A, 242, ALA, O | 3.35Å |
| A, 238, ILE, HA | B, 237, GLY, O | 2.62Å |
| A, 241, GLY, HA1 | B, 238, ILE, O | 2.59Å |
| A, 242, ALA, HA | B, 241, GLY, O | 2.41Å |
| A, 245, GLY, HA1 | B, 242, ALA, O | 3.35Å |
