Leucine-rich repeat-containing protein 25

UniProt data

UniProt name: LRC25_HUMAN (Q8N386)

Gene name: LRRC25; Synonyms=MAPA; ORFNames=UNQ6169/PRO20174

Organism: Homo sapiens (Human).

Function: May be involved in the activation of cells of innate and acquired immunity. {ECO:0000269|PubMed:12384430}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 166-186, 21 AA, Helical. {ECO:0000255}.

Sequence: 305 AA

10 20 30 40 50 60 MGGTLAWTLL LPLLLRESDS LEPSCTVSSA DVDWNAEFSA TCLNFSGLSL SLPHNQSLRA 70 80 90 100 110 120 SNVILLDLSG NGLRELPVTF FAHLQKLEVL NVLRNPLSRV DGALAARCDL DLQADCNCAL 130 140 150 160 170 180 ESWHDIRRDN CSGQKPLLCW DTTSSQHNLS AFLEVSCAPG LASATIGAVV VSGCLLLGLA 190 200 210 220 230 240 IAGPVLAWRL WRCRVARSRE LNKPWAAQDG PKPGLGLQPR YGSRSAPKPQ VAVPSCPSTP 250 260 270 280 290 300 DYENMFVGQP AAEHQWDEQG AHPSEDNDFY INYKDIDLAS QPVYCNLQSL GQAPMDEEEY VIPGH

CATM prediction

The sequence of LRC25_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         170       180       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SATIGAVVVSGCLLLGLAIAGAVLAWR 7.0 -51.6° 1.3 57.1 -16.2
Model 2 SATIGAVVVSGCLLLGLAIAGAVLAWR 7.3 -45.0° 0.2 44.8 -12.1
Model 3 SATIGAVVVSGCLLLGLAIAGAVLAWR 6.9 -46.0° 4.7 38.0 -4.0
Prolines* SATIGAVVVSGCLLLGLAIAGPVLAWR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 175, LEU, HA A, 174, CYS, O 3.17Å
B, 178, GLY, HA1 A, 175, LEU, O 2.89Å
B, 179, LEU, HA A, 178, GLY, O 3.42Å
A, 175, LEU, HA B, 174, CYS, O 3.17Å
A, 178, GLY, HA1 B, 175, LEU, O 2.89Å
A, 179, LEU, HA B, 178, GLY, O 3.42Å