Voltage-dependent calcium channel beta subunit-associated regulatory protein {ECO:0000305}

UniProt data

UniProt name: CBARP_HUMAN (Q8N350)

Gene name: CBARP {ECO:0000312|HGNC:HGNC:28617}

Organism: Homo sapiens (Human).

Function: Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}.

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q66L44}; Single- pass type III membrane protein {ECO:0000250|UniProtKB:Q66L44}. Cell membrane {ECO:0000250|UniProtKB:Q66L44}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q66L44}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q66L44}.

Transmembrane domains:

  1. 46-66, 21 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 705 AA

10 20 30 40 50 60 MQPTATMATA ATTTTTTTAT VALTTSWDNA TGRPTAEPDP ILDNYVLLVV VMSLFVGGTL 70 80 90 100 110 120 VVLSGVLLLC KRCWDVHQRL NRAMEEAEKT TTTYLDNGTH PAQDPDFRGE DPECQDAETE 130 140 150 160 170 180 RFLSTSSTGR RVSFNEAALF EQSRKTQDKG RRYTLTEGDF HHLKNARLTH LHLPPLKIVT 190 200 210 220 230 240 IHECDSGEAS SATTPHPATS PKATLAIFQP PGKALTGRSV GPSSALPGDP YNSAAGATDF 250 260 270 280 290 300 AEISPSASSD SGEGTSLDAG TRSTKAGGPG AAAGPGEAGP GSGAGTVLQF LTRLRRHASL 310 320 330 340 350 360 DGASPYFKVK KWKLEPSQRA ASLDTRGSPK RHHFQRQRAA SESTEQEEGD APQEDFIQYI 370 380 390 400 410 420 ARAGDAVAFP HPRPFLASPP PALGRLEAAE AAGGASPDSP PERGAGSAGP EQQQPPLEPD 430 440 450 460 470 480 AERDAGPEQA QTSYRDLWSL RASLELHAAA SDHSSSGNDR DSVRSGDSSG SGSGGAAPAF 490 500 510 520 530 540 PPPSPPAPRP KDGEARRLLQ MDSGYASIEG RGAGDDTEPP AAPARPRSPR AWPRRPRRDY 550 560 570 580 590 600 SIDEKTDALF HEFLRHDPHF DDTPAAARHR ARAHPHARKQ WQRGRQHSDP GARAAPALAG 610 620 630 640 650 660 TPAPPAGAAR PARAPLRRGD SVDGPPDGRT LGGAGDDPAI PVIEEEPGGG GCPGSGLCVL 670 680 690 700 PSGSVLDKLA AGLDERLFPP RLAEPVVATP ALVAAAPTSP DHSPA

CATM prediction

The sequence of CBARP_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     40        50        60  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 DNYVLLVVVMSLFVGGTLVVLSGVLLL 7.3 -55.0° 2.4 47.8 -12.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 48, LEU, HA A, 47, SER, O 3.46Å
B, 51, GLY, HA1 A, 48, LEU, O 3.23Å
A, 48, LEU, HA B, 47, SER, O 3.46Å
A, 51, GLY, HA1 B, 48, LEU, O 3.23Å